Denigma

TH

Symbol: TH
Name: tyrosine hydroxylase
Entrez gene ID: 7054
Ensembl gene ID: ENSG00000180176
Species: Human (Taxid: 9606)


Observation:

Polymorphyc repeats in intron 1 (Short and Long alleles) of the TH gene were examined in 196 centenarians (143 females and 53 males) and 358 controls (196 females and 162 male; 10-85 years old). A significant loss of LL homozygous genotypes was found at the THO locus in male but not in female centenarians with respect to matched controls [9887369].TH was found to be associated with longevity [12297342]. TH was found to be associated with longevity [21407269]. TH was found to be associated with longevity [19367319]. TH was not found to be associated with longevity [19367319]. TH was found to be associated with longevity [11053670]. TH was found to be associated with longevity [17989723].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • many SNPs 0.05 [19367319]
  • - 0.05 [19367319]
  • - 0.045 [11053670]
  • length (STR polymorphism) 1.0 [21407269]
  • HUMTHO1.STR 0.005 [12297342]

    • Classification:
  • Longevity-Associated
  • No Age Effect


    • Type:
  • Gene
  • Protein coding

    References:
  • 9887369: Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2).


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • TH (9606)
  • TH (9598)
  • TH (9615)
  • TH (9913)
  • Th (10090)
  • Th (10116)
  • TH (9031)
  • th (7955)
  • ple (7227)
  • AgaP_AGAP006023 (7165)
  • cat-2 (6239)

    • Inparanoids
  • ENSMUSP00000000219 (10090)
  • ENSRNOP00000027682 (10116)
  • ENSMMUP00000005218 (9544)
  • ENSP00000370571 (9606)



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