HSPA1L

Symbol: HSPA1L
Name: heat shock 70kDa protein 1-like
Entrez gene ID: 3305
Ensembl gene ID: ENSG00000204390
Species: Human (Taxid: 9606)


Observation:

The frequency of the T2437C transversion (Met to Thr) polymorphism in the HSPA1L gene was investigated in a healthy aged population of 100 control samples (59% female, 41% male with an age-range of 19-45 years) and 129 aged consecutive samples (70% female, 30% male with an age range of 80-97 years). The 2437T polymorphic nucleotide was observed to increase in the elderly, although not attaining statistical significance. The TT genotype was observed to be significantly increased within the aged population, while conversely the TC genotype was significantly decreased in the aged subjects [12742533].HSPA1L was found to be associated with longevity [12742533]. HSPA1L was found to be associated with longevity [16804002]. HSPA1L was found to be associated with longevity [16804002].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs2227956 0.328 [20388090]
  • rs1061581-rs1043618-rs2227956 0.016 [19840767]
  • rs1061581-rs1043618-rs2227956 0.025 [19840767]
  • rs1061581 0.04 [16804002]
  • rs2227956 None [16804002]
  • 2437 T>C 0.01 [12742533]

  • Classification:
  • Longevity-Associated


  • Type:
  • Gene
  • Protein coding

    References:
  • 12742533: Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HSPA1L (9606)
  • HSPA1L (9598)
  • HSPA1L (9615)
  • HSPA1L (9913)
  • Hspa1l (10090)
  • LOC798846 (7955)
  • zgc:174006 (7955)
  • hsp70l (7955)
  • hsp70 (7955)
  • Hsp70b (3702)
  • PF08_0054 (5833)



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