Symbol: EXO1 Name: exonuclease 1 Entrez gene ID: 9156 Ensembl gene ID: ENSG00000174371 Species: Human (Taxid: 9606) Function: DNA repair Observation: The rs1776180 C allele in the promoter of EXO1 is significantly enriched in female Germans centenarians and this can be replicated in 445 female French centenarians. The C allele leads to the loss of binding site for the basic helix-loop-helix transcription factor E47, resulting in higher EXO1 expression [19698732].EXO1 was found to be associated with longevity [19698732]. EXO1 was not found to be associated with longevity [23770741]. Assays: Organismal Lifespan Longevity Associated Variants: Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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