IL6

Symbol: IL6
Name: interleukin 6 (interferon, beta 2)
Alias: HGF; HSF; BSF2; IL-6; IFNB2; B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; CDF; CTL differentiation factor; IFN-beta-2; hybridoma growth factor; interferon beta-2; interleukin BSF-2; interleukin-6
Entrez gene ID: 3569
Ensembl gene ID: ENSG000001
Species: Human (Taxid: 9606)

Function:
Interleukin that acts as both a pro- and anti-inflammatory cytokine.

Observation:

Elevated IL-6 serum levels are associated with diseases, disability and mortality in the elderly. The proportion of homozyogtes for the G allele at -174 locus (a promoter genetic variability) decreases centenarian males, but not centenarians females. Only males, homozygous for the G allele at -174 locus have higher IL6- serum levels. Individuals who are genetically predisposed to produce high levels of IL-6 during aging (i.e. -174 locus GG homozygous men) are disadvantaged for longevity [11500818].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs2069827 0.064 [22234866]
  • VNTR polymorphism 0.07 [17506774]
  • rs1800795 0.23 [11640949]
  • rs1800795 None [15236771]
  • rs1800795 + (rs429358, rs7412) 0.45 [15236771]

  • Classification:
  • Aging Associated
  • Longevity-Associated


  • References:
  • 11500818: A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • IL6 (9606)
  • IL6 (9598)
  • IL6 (9615)
  • IL6 (9913)
  • Il6 (10090)
  • Il6 (10116)
  • IL6 (9031)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit