Symbol: IL6 Name: interleukin 6 (interferon, beta 2) Alias: HGF; HSF; BSF2; IL-6; IFNB2; B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; CDF; CTL differentiation factor; IFN-beta-2; hybridoma growth factor; interferon beta-2; interleukin BSF-2; interleukin-6 Entrez gene ID: 3569 Ensembl gene ID: ENSG000001 Species: Human (Taxid: 9606) Function: Interleukin that acts as both a pro- and anti-inflammatory cytokine. Observation: Elevated IL-6 serum levels are associated with diseases, disability and mortality in the elderly. The proportion of homozyogtes for the G allele at -174 locus (a promoter genetic variability) decreases centenarian males, but not centenarians females. Only males, homozygous for the G allele at -174 locus have higher IL6- serum levels. Individuals who are genetically predisposed to produce high levels of IL-6 during aging (i.e. -174 locus GG homozygous men) are disadvantaged for longevity [11500818]. Assays: Organismal Lifespan Longevity Associated Variants: Classification: References: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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