CETP

Symbol: CETP
Name: cholesteryl ester transfer protein, plasma
Entrez gene ID: 1071
Ensembl gene ID: ENSG00000087237
Species: Human (Taxid: 9606)

Functional description:
Cholesteryl ester transfer protein involved in the regulation of cholesterol transport and high-density lipoprotein (HDL) levels.; Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. [UniProt]

Observation:

Homozygousity for the I405V variant of CETP is associated with exceptional longevity and larger HDL and LDL particle sizes as well as lower prevalence of hypertension, cardivascular disease, and metabolic disease among Askenazi Jews [14559957]. CETP I405V homozygousity is associated with exceptional longevity and preservation of cognitive function in Askenazi Jews [17190939].

V/V homozygotes tend to have a 9-23% CETP deficiency [9610775; 15243211]. A decrease in CETP function increases HDL (high density lipoproteins) levels in the body, and decreases LDL (low-density lipoprotein). The result of this s that HDL-c levels are approximately equal in individuals with the I/I or I/V genotypes, while there are ten percent higher in V/V individuals [9610775].

Therefore the V/V SNP acts kind like an endogenous CEPT inhibitor, which might be the responsible for the increase in longevity but may also have side effects.CETP was found to be associated with longevity [22336474].CETP was found to be associated with longevity [15621216].CETP was found to be associated with longevity [15888337]. CETP was found to be associated with longevity [22234866]. CETP was found to be associated with longevity [22336474]. CETP was found to be associated with longevity [23389097]. CETP was found to be associated with longevity [23389097]. CETP was found to be associated with longevity [15621216]. CETP was found to be associated with longevity [15888337]. CETP was not found to be associated with longevity [23389097]. CETP was found to be associated with longevity [14559957]. CETP was found to be associated with longevity [16602826]. CETP was found to be associated with longevity [23162014]. CETP was not found to be associated with longevity [14559957]. CETP was found to be associated with longevity [18034366]. CETP was not found to be associated with longevity [24468472].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs708272 1.0 [23389097]
  • rs5882 1.0 [23389097]
  • rs9923854 0.001 [22234866]
  • rs5882 0.05 [15621216]
  • rs708272 0.068 [22336474]
  • rs5882 0.318 [15888337]
  • rs1800775 0.02 [23083790]
  • rs708272 0.02 [23083790]
  • rs708272 0.439 [15888337]
  • rs5882 0.069 [16602826]
  • rs5882 0.001 [14559957]
  • rs5882 0.041 [18034366]
  • rs5882 0.63 [24468472]
  • rs708272 0.53 [24468472]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene
  • Protein coding

    References:
  • 14559957: Unique lipoprotein phenotype and genotype associated with exceptional longevity.
  • 17190939: A genotype of exceptional longevity is associated with preservation of cognitive function.
  • 9610775: Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia.
  • 15243211: CETP gene variation: relation to lipid parameters and cardiovascular risk.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CETP (9606)
  • CETP (9598)
  • CETP (9031)
  • cetp (7955)

  • Inparanoids
  • ENSMMUP00000023122 (9544)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit