DR-Mimetic (DRM)

A DR-mimetic can either be a genetic intervention or a small component that mimics the lifespan extending effect of Dietary Restriction (DR). Manipulation of DR-mimetic genes lead to an increased lifespan for ad libitum-fed animals which is not further extended by DR. Similar DR-mimetic drugs extend the lifespan on ad libitum which is non-additive in lifespan extension effect of a restricted diet.

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