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Ensembl gene ID:
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Please provide references to the evidence why this factor was chosen to be classified. In the ideal case provide a PMID in square brackets at the end of the sentence. Multiple PMIDs can be separated by semicolon, e.g. "The gene XYZ was associated with aging in some way [12345; 67890].
Age-Related Disease Associated
No Age Effect
Stem Cell Related
Deletion of mitochondrial DNA
Transplantation of young thymus
High-temperature pulse (HTP)
Buffering pH to 6.0
Reducing Protein Synthesis
Impairing Chemosensory Perception
Impairing mitochondrial electron transport
Dietary restriction on low-fat diet
Dietary restriction on high-fat diet
High fat diet
Germ-cell precursor ablation
ectopic Trp53 overexpression
Whole-body Sirt1 deletion in the adulthood
Overexpression of constitutive nuclear SKN-1
Inhibition of TOR signaling
Tert gene therapy
Defects in the cilia of dendritic nerve endings
Selection for starvation resistance
Vitamin C treatment
Icariside II treatment
Gh antagonist overexpression
30% Dietary restriction
Dietary restriction by 1% yeast medium
Malnutrition by 0.2% yeast medium
p53 dominant negative overexpression
Dominant negative Tor
Constitutive active S6k overexpression
Homozygous chico mutation
Heterzygous chico mutation
Heterozygous hypomorphic Rpd3 mutation
Heterzygous Rpd3 null mutation
Apply polyphenol treatment
Inactivation Wnt/b-catenin signaling
Increasing JNK signaling
Replacement of Cebpa by Cebpb
Overexpression of Cat and Sod1
Transient CDC7 inactivation
High sugar low protein diet
Low calorie diet with low-sugar content
Heterozyogous fat-specific Insr knockout (FIRKO)
Overexpression of ucp2 and aakg-2
p53 deletion mutation
Neural-specific POSH overexpression
mld heterozygous mutation
Heterozygous Gh1 anti-sense transgene
Homozygous Gh1 anti-sense transgene
Homozygous GH1 deletion
hypomoprhic hep mutation
Ubiquitinous SOD1 overexpression
InRE19/InRp5545 transheterozygous mutation
InrGC25/InrE19 transheterozygous mutation
Activating let-60 mutation
Mating type heterozygosity
Overexpression of mitochondrial targeted CAT
MSN2 MSN4 double mutation
Heterozyogus Shc1 knockout
Homozygous Shc1 knockout
PLD alpha antisense
Homozygous knock-in of proof-reading deficient Polg
Homozygous Prdx1 knockout
SGS101 antisense RNAi
SGS101 chemical induced overexpression
SIR3 activating mutation
Sod2 homozygous knockout
Sod2 heterozyogous knockout
Eleutherococcus senticosus treatment
Rhodiola rosea treatment
Overexpression of truncated TLC1
Heterozyogus Trp53 truncation mutation
NDT80 transient overexpression
IME1 transient overexpression
Elevation of histone expression
Dnmt gene therapy
Inhibition of mitochondrial respiration
Ganodermasides C treatment
Restriction of yeast
Fat-body specific Akh knockdown
Gonadermasides D treatment
Ganodermasides A treatment
Ganodermasides B treatment
git3 constitutive activative mutation
gpa2 constitutive active mutation
wis1 constitutive active mutation
SFA1 YHB1 double mutation
FKH1 FKH2 deletion
TSA1 activating mutation
NDE1 NDE2 overexpression
Overexpression of constitutive nuclear DAF-16
aak-2 constitutive active mutation
Blueberry extract supplementation
Apple polyphenol supplementation
Black tea extract supplementation
Beauveriolide I treatment
Hsp70 locus overexpression
Cynomorium songaricum supplementation
Black rice extract supplementation
lin-14 loss-of-function mutation
lin-14 gain-of-function mutation
Lamp2a expression restoration
mir-61 mir-250(nDf59) mutation
mir-64-66 mir-229(nDf63) mutation
mir-80 mir-227(nDf53); mir-81-82(nDf54)
Olive oil treatment
C60-olive oil treatment
Carboxyfullerene SOD mimetic treatment
Bub3 and Rae1 haploinsuficiency
ERCC1 and ERCC4 deficieny
sdhC dominant negative overexpression
Trichostatin A supplementation
Hsp22 doxycyline-regulated overexpression
Hsp22-promoter driven reporter overexpression
Ablation of median neurosecretary cells
Constitutive miR-277 expression
11251834 Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis.
20346071 Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.
22225495 Metabotyping of long-lived mice using 1H NMR spectroscopy.
15096581 Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans.
15574588 The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.
12750520 Mitochondrial dysfunction in the elderly: possible role in insulin resistance.
21386131 Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants.
19301819 Quantitative lipid analysis and life span of the fat-3 mutant of Caenorhabditis elegans.
18423200 Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.
15383542 Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae.
10224252 Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae.
19801973 Induction of autophagy by spermidine promotes longevity.
19954334 Noninvasive neonatal thymus graft into the axillary cavity extends the lifespan of old mice.
11707916 Longevity and aging: beneficial effects of exposure to mild stress.
10219000 Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans.
22484922 Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.
17986602 Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span.
18029465 Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women.
10495400 DHEA deficiency syndrome: a new term for old age?
9215277 Dehydroepiandrosterone sulfate: a biomarker of primate aging slowed by calorie restriction.
20696905 Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity.
21076178 Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence.
12586694 SOD2 functions downstream of Sch9 to extend longevity in yeast.
19686215 A high-throughput screen for chemicals that increase the lifespan of Caenorhabditis elegans.
22496578 Frontostriatal white matter integrity mediates adult age differences in probabilistic reward learning.
22482728 Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal.
9999999 Structural relaxation and defect annihilation in pure amorphous silicon.
17411345 Lifespan regulation by evolutionarily conserved genes essential for viability.
16741121 Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans.
17608836 Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan.
8136829 Genetic associations with human longevity at the APOE and ACE loci.
10818513 Severity of cardiovascular disease, apolipoprotein E genotype, and brain pathology in aging and dementia.
8624216 Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition.
8541369 Apolipoprotein E allele frequencies in an Italian population: relation to age and lipid profile.
9105559 Analysis of the apo E/apo C-I, angiotensin converting enzyme and methylenetetrahydrofolate reductase genes as candidates affecting human longevity.
12185856 Analysis of the association between apolipoprotein E polymorphism and cardiovascular risk factors in an elderly population with longevity.
15621215 Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study.
16971231 Analysis of common polymorphisms in angiotensin-converting enzyme and apolipoprotein e genes and human longevity in Colombia.
3864931 Ataxia-telangiectasia: genetics, neuropathology, and immunology of a degenerative disease of childhood. Proceedings of a conference. Solvang, California, January 16-20, 1984.
16103914 New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen.
12471266 Rates of behavior and aging specified by mitochondrial function during development.
15998808 A systematic RNAi screen for longevity genes in C. elegans.
12242224 A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae.
18340043 Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.
22504417 Identification of common variants associated with human hippocampal and intracranial volumes.
22504421 Common variants at 12q14 and 12q24 are associated with hippocampal volume.
22509016 Midlife gene expressions identify modulators of aging through dietary interventions.
18059442 A modular network model of aging.
12447374 A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity.
8638122 Determination of life-span in Caenorhabditis elegans by four clock genes.
11000115 Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
19074434 Complex I function is defective in complex IV-deficient Caenorhabditis elegans.
8247153 A C. elegans mutant that lives twice as long as wild type.
1448167 Production of sperm reduces nematode lifespan.
22103665 Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan.
17392428 Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex.
17912023 Autophagy is required for dietary restriction-mediated life span extension in C. elegans.
20041217 TGF-beta Sma/Mab signaling mutations uncouple reproductive aging from somatic aging.
21413222 Genetic and Environmental Regulation of Dauer Larva Development
17900898 The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling.
20657825 Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation.
21123740 Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.
9371826 A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse).
12933651 Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.
12426394 "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally.
11780111 p53 mutant mice that display early ageing-associated phenotypes.
15520276 Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.
22950424 Systems Biology and Bioinformatics in Aging Research: A Workshop Report.
22405073 Pten positively regulates brown adipose function, energy expenditure, and longevity.
22560220 SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
18828672 Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.
19587680 Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
22560223 TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
18358814 Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
19079239 Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans.
15253933 The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.
17266679 Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.
15296714 Role and regulation of starvation-induced autophagy in the Drosophila fat body.
22574120 C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline.
12826401 The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
16860373 C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.
11242085 Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
16530049 SMK-1, an essential regulator of DAF-16-mediated longevity.
17476212 PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
15905404 Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
11799246 Regulation of life-span by germ-line stem cells in Caenorhabditis elegans.
12743030 Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1.
15200950 A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1.
17612494 E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.
18043729 Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.
19302372 Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae.
20953148 Endosomal protein sorting and autophagy genes contribute to the regulation of yeast life span.
22576335 MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping.
19013273 Telomerase reverse transcriptase delays aging in cancer-resistant mice.
15688016 Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.
21113150 Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.
22585399 Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer.
13678781 Bone development and age-related bone loss in male C57BL/6J mice.
2921472 Studies in the distribution of body fat: I. Effects of age, sex, and obesity.
3322823 Insulin-like growth factors and aging.
16957737 p16INK4a induces an age-dependent decline in islet regenerative potential.
16957738 Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.
15734685 Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone.
11919569 The aging of lympho-hematopoietic stem cells.
18283121 The longest telomeres: a general signature of adult stem cell compartments.
16582880 Increased p53 activity does not accelerate telomere-driven ageing.
21937764 Indy knockdown in mice mimics elements of dietary restriction.
16782295 Increased lifespan in transgenic Caenorhabditis elegans overexpressing human alpha-synuclein.
18331616 Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.
19239417 Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans.
19229346 Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans.
10617200 Regulation of lifespan by sensory perception in Caenorhabditis elegans.
19293945 A human protein interaction network shows conservation of aging processes between human and invertebrate species.
9768365 Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene.
11591319 The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans.
12845331 Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.
19747233 The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet.
21436897 Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae.
18690010 A life-span extending form of autophagy employs the vacuole-vacuole fusion machinery.
16293764 Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
22612594 The number of p16INK4a positive cells in human skin reflects biological age.
22559237 Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension.
17662940 Type 5 adenylyl cyclase disruption increases longevity and protects against stress.
19536287 Disruption of protein kinase A in mice enhances healthy aging.
22377630 Ribosome deficiency protects against ER stress in Saccharomyces cerevisiae.
21151885 A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.
18832074 SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
22216122 Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.
22653297 Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila.
21855561 Curcumin-mediated lifespan extension in Caenorhabditis elegans.
22348084 Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.
19043800 Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.
19370397 Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16.
16682650 Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction.
21930912 Increased transsulfuration mediates longevity and dietary restriction in Drosophila.
20195512 Molecular evolution and functional characterization of Drosophila insulin-like peptides.
19804760 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.
19968629 Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila.
19747824 Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain.
16303568 Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span.
15732191 Variation in the human TP53 gene affects old age survival and cancer mortality.
15175753 Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body.
18241326 Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response.
19470468 Long-lived Indy and calorie restriction interact to extend life span.
11118146 Extended life-span conferred by cotransporter gene mutations in Drosophila.
12626742 Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies.
17571923 No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects.
15520384 Sir2 mediates longevity in the fly through a pathway related to calorie restriction.
15186745 Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
11292874 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
11951037 Dietary restriction in long-lived dwarf flies.
17272684 Regulation of Drosophila life span by olfaction and food-derived odors.
12459580 Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.
16387864 Involvement of Drosophila uncoupling protein 5 in metabolism and aging.
18662544 An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans.
21562563 N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans.
22132200 The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans.
17081160 Lifespan extension in Caenorhabditis elegans by complete removal of food.
17096674 Dietary deprivation extends lifespan in Caenorhabditis elegans.
16387300 Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons.
21334311 The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans.
21040400 Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans.
19783783 Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans.
19812672 Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans.
19924292 Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling.
19883616 Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression.
18219227 Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.
22291164 Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
20717869 Procyanidins from apples (Malus pumila Mill.) extend the lifespan of Caenorhabditis elegans.
19164523 The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span.
18043747 DAF-2/insulin-like signaling in C. elegans modifies effects of dietary restriction and nutrient stress on aging, stress and growth.
22661501 A persistent level of Cisd2 extends healthy lifespan and delays aging in mice.
19451219 Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice.
22661237 The second international conference "genetics of aging and longevity".
8195187 Cloning and characterization of LAG1, a longevity-assurance gene in yeast.
12598614 blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration.
12958363 Autophagy genes are essential for dauer development and life-span extension in C. elegans.
18282106 A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.
5770175 Bloom's syndrome. I. Genetical and clinical observations in the first twenty-seven patients.
21447998 A genomic analysis of chronological longevity factors in budding yeast.
14602080 JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.
15208629 BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.
15289464 Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells.
10982846 C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue.
8108730 Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.
9858546 FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies.
11805047 Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity.
12620118 A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes.
9428525 Extrachromosomal rDNA circles--a cause of aging in yeast.
8552037 The genomic instability of yeast cdc6-1/cdc6-1 mutants involves chromosome structure and recombination.
11756539 hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae.
2698814 Replication control and cellular life span.
1990268 A role for CDC7 in repression of transcription at the silent mating-type locus HMR in Saccharomyces cerevisiae.
12136014 Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation.
10873623 Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans.
14559957 Unique lipoprotein phenotype and genotype associated with exceptional longevity.
1732156 Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.
2428682 Mutant sensory cilia in the nematode Caenorhabditis elegans.
10508861 Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo.
7705621 Mutations affecting the chemosensory neurons of Caenorhabditis elegans.
1986232 Intramitochondrial functions regulate nonmitochondrial citrate synthase (CIT2) expression in Saccharomyces cerevisiae.
14156156 COCKAYNE'S SYNDROME. A REPORT OF FIVE NEW CASES WITH BIOCHEMICAL, CHROMOSOMAL, DERMATOLOGIC, GENETIC AND NEUROPATHOLOGIC OBSERVATIONS.
514720 The Cockayne syndrome: an evaluation of hypertension and studies of renal pathology.
9020081 Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.
11136229 A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants.
9789046 The genetics of caloric restriction in Caenorhabditis elegans.
7768437 Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.
11959146 CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA.
10202142 CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans.
10330149 Mitochondrial group II introns, cytochrome c oxidase, and senescence in Podospora anserina.
2999848 A 1100-bp sequence of mitochondrial DNA is involved in senescence process in Podospora: study of senescent and mutant cultures.
10759557 A causal link between respiration and senescence in Podospora anserina.
11361336 Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing of nondividing cells.
12024027 Mutations in DNA replication genes reduce yeast life span.
10335847 A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.
12610632 A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.
12124627 Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration.
16311627 Increased life span due to calorie restriction in respiratory-deficient yeast.
22672579 Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster.
8900272 Dwarf mice and the ageing process.
8100276 Premature ageing in transgenic mice expressing different growth hormone genes.
14583653 Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice.
11718806 The Snell dwarf mutation Pit1(dw) can increase life span in mice.
11371619 Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production.
10875265 Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.
12483226 IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
12543978 Extended longevity in mice lacking the insulin receptor in adipose tissue.
9363890 Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
16123266 Suppression of aging in mice by the hormone Klotho.
11744049 Dietary restriction alters cell proliferation in rats: an immunohistochemical study by labeling proliferating cell nuclear antigen.
22661299 Chronic caloric restriction partially protects against age-related alteration in serum metabolome.
7789761 Genes that regulate both development and longevity in Caenorhabditis elegans.
10360574 Signals from the reproductive system regulate the lifespan of C. elegans.
8807293 Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation.
7219552 Interacting genes in nematode dauer larva formation.
19460140 A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study.
11747825 daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans.
16720740 daf-16 protects the nematode Caenorhabditis elegans during food deprivation.
22265419 HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity.
16153634 Lifespan and dauer regulation by tissue-specific activities of Caenorhabditis elegans DAF-18.
8601482 The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.
9475731 Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans.
10428762 The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans.
9504918 An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans.
8005442 A screen for nonconditional dauer-constitutive mutations in Caenorhabditis elegans.
11782415 DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity.
11740945 A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span.
3350212 Mutants of Caenorhabditis elegans that form dauer-like larvae.
12935877 In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila.
10521401 The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
3158266 Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome.
11868902 Neural-specific overexpression of drosophila plenty of SH3s (DPOSH) extends the longevity of adult flies.
12610309 Steroid control of longevity in Drosophila melanogaster.
8462849 The genetics of feeding in Caenorhabditis elegans.
2508089 Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.
12571101 Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans.
15533947 DNA methyltransferase gene dDnmt2 and longevity of Drosophila.
9794765 Extended life-span and stress resistance in the Drosophila mutant methuselah.
8582611 Regulation of gene expression is linked to life span in adult Drosophila.
9799084 The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type.
11065130 A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains.
11778046 Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q.
10230397 Elimination of replication block protein Fob1 extends the life span of yeast mother cells.
2341035 fog-1, a regulatory gene required for specification of spermatogenesis in the germ line of Caenorhabditis elegans.
10747056 Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans.
11076749 FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline.
7713418 The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans.
12000449 Overexpression of Arabidopsis thaliana farnesyl diphosphate synthase (FPS1S) in transgenic Arabidopsis induces a cell death/senescence-like response and reduced cytokinin levels.
10921902 Sip2p and its partner snf1p kinase affect aging in S. cerevisiae.
12057928 Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model.
12915652 Reduced longevity in untreated patients with isolated growth hormone deficiency.
16581512 Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan.
16581513 Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila.
12391171 High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction.
8804410 GRISEA, a putative copper-activated transcription factor from Podospora anserina involved in differentiation and senescence.
9271578 Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.
12213553 Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast.
10512855 Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.
8962081 HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription.
8754818 Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae.
9635192 Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.
9501103 Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing.
11861900 SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases.
11290710 The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination.
14668486 Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones.
22737247 Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.
12882326 Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals.
11959102 Extended longevity of Caenorhabditis elegans by knocking in extra copies of hsp70F, a homolog of mot-2 (mortalin)/mthsp70/Grp75.
17908928 Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p.
8643570 Heat-shock protein 104 expression is sufficient for thermotolerance in yeast.
9851879 Heat stress-induced life span extension in yeast.
15308776 Multiple-stress analysis for isolation of Drosophila longevity genes.
9454332 Extension of life-span by introduction of telomerase into normal human cells.
10719757 Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice.
8610185 Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.
1763030 Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase.
11408621 Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles.
12230882 Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span.
19030232 Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity.
11292875 A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.
11274053 Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.
11709184 Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.
10631108 Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys.
11016890 Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging.
10198056 Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins.
9872981 Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.
8760941 LAG2, a gene that determines yeast longevity.
14668850 Genetics: influence of TOR kinase on lifespan in C. elegans.
16164423 LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans.
12383511 Cytoplasmic SIR2 homologue overexpression promotes survival of Leishmania parasites by preventing programmed cell death.
11526246 A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4.
10326548 Siblings of centenarians live longer.
8454201 a/alpha-control of DNA repair in the yeast Saccharomyces cerevisiae: genetic and physiological aspects.
8625846 The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts.
1783292 Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans.
9716135 A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.
2233820 A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans.
15879174 Extension of murine life span by overexpression of catalase targeted to mitochondria.
9891081 Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.
6879195 Evidence for the recessive nature of cellular immortality.
3413074 Genetic analysis of indefinite division in human cells: identification of four complementation groups.
10838077 Inactivation of p53 and life span extension of human diploid fibroblasts by mot-2.
8454632 Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype.
17172436 Mpt5p, a stress tolerance- and lifespan-promoting PUF protein in Saccharomyces cerevisiae, acts upstream of the cell wall integrity pathway.
7845352 A new yeast gene, HTR1, required for growth at high temperature, is needed for recovery from mating pheromone-induced G1 arrest.
9584615 Molecular mechanisms of yeast aging.
7859289 Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.
9150138 Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.
9504907 Dhh1p, a putative RNA helicase, associates with the general transcription factors Pop2p and Ccr4p from Saccharomyces cerevisiae.
14741356 Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae.
18225956 Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9.
11867705 High-quality life extension by the enzyme peptide methionine sulfoxide reductase.
16611701 Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies.
15911777 No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans.
8810036 Review: to bud until death: the genetics of ageing in the yeast, Saccharomyces.
7586026 NCA3, a nuclear gene involved in the mitochondrial expression of subunits 6 and 8 of the Fo-F1 ATP synthase of S. cerevisiae.
22310715 Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila.
17173038 Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models.
15719061 Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans.
2406721 Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria.
12736687 Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.
20947565 Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae.
17482543 Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.
17110466 Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging.
10841563 A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.
11884393 Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.
12668588 Hypotension and reduced catecholamines in neuropeptide Y transgenic rats.
15276593 Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men.
11861554 Roles for Caenorhabditis elegans rad-51 in meiosis and in resistance to ionizing radiation during development.
7714894 Exclusive expression of C. elegans osm-3 kinesin gene in chemosensory neurons open to the external environment.
8348618 Odorant-selective genes and neurons mediate olfaction in C. elegans.
730048 Osmotic avoidance defective mutants of the nematode Caenorhabditis elegans.
10617470 A delayed wave of death from reproduction in Drosophila.
10580504 The p66shc adaptor protein controls oxidative stress response and life span in mammals.
4735177 Paralysis agitans of early onset with marked diurnal fluctuation of symptoms.
15105378 Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.
11742076 Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase.
2827010 SRA5 encodes the low-Km cyclic AMP phosphodiesterase of Saccharomyces cerevisiae.
10394911 The oxidative stress response mediated via Pos9/Skn7 is negatively regulated by the Ras/PKA pathway in Saccharomyces cerevisiae.
10364160 A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
15155758 Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans.
9741628 PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans.
9259555 The prohibitin family of mitochondrial proteins regulate replicative lifespan.
9060969 Transgenic mice overexpressing urokinase-type plasminogen activator in the brain exhibit reduced food consumption, body weight and size, and increased longevity.
9437863 Antisense suppression of phospholipase D alpha retards abscisic acid- and ethylene-promoted senescence of postharvest Arabidopsis leaves.
10934557 Molecular genetics of Alzheimer's disease: what have we learned?
8034612 Divergent roles of RAS1 and RAS2 in yeast longevity.
19633237 Overexpression of Mn superoxide dismutase does not increase life span in mice.
21700873 Gametogenesis eliminates age-induced cellular damage and resets life span in yeast.
20832724 Elevated histone expression promotes life span extension.
11292860 Regulation of longevity and stress resistance by Sch9 in yeast.
22790951 New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound.
22279548 Genetic signatures of exceptional longevity in humans.
19837933 Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity.
19915151 Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians.
17190939 A genotype of exceptional longevity is associated with preservation of cognitive function.
18059160 Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.
21687659 Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.
23144747 Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.
22930061 Black rice extract extends the lifespan of fruit flies.
21281604 A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila.
22366109 Misexpression screen delineates novel genes controlling Drosophila lifespan.
22970337 Apple can act as anti-aging on yeast cells.
23028355 C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.
23028268 Ten simple rules for online learning.
12939617 Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
15254550 Sirtuin activators mimic caloric restriction and delay ageing in metazoans.
17460219 Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans.
17875315 Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans.
17086191 Resveratrol improves health and survival of mice on a high-calorie diet.
18599363 Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
17578509 An Aging Interventions Testing Program: study design and interim report.
20974732 Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
16435200 Deletion of the Caenorhabditis elegans homologues of the CLN3 gene, involved in human juvenile neuronal ceroid lipofuscinosis, causes a mild progeric phenotype.
15130665 Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death.
16527275 Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast.
10662670 Two paralogs involved in transcriptional silencing that antagonistically control yeast life span.
22622083 Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion.
23066506 The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.
21325893 Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila.
21857805 Sex chromosome-specific regulation in the Drosophila male germline but little evidence for chromosomal dosage compensation or meiotic inactivation.
11462771 Antioxidant and antiaging activity of N-acetylserotonin and melatonin in the in vivo models.
18212404 Does melatonin play a role in aging processes?
21641548 Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling.
17369827 Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster.
17855453 Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants.
17933869 Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level.
17567437 Thioredoxin-2 affects lifespan and oxidative stress in Drosophila.
17435236 Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.
17301052 Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila.
22768842 Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster.
20519778 Comparative transcriptional profiling identifies takeout as a gene that regulates life span.
18434551 Drosophila germ-line modulation of insulin signaling and lifespan.
20036725 Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22.
14734639 Overexpression of the small mitochondrial Hsp22 extends Drosophila life span and increases resistance to oxidative stress.
17651920 Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits.
17617737 Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila.
12882345 The shortened replicative life span of prohibitin mutants of yeast appears to be due to defective mitochondrial segregation in old mother cells.
11744041 Loss of prohibitins, though it shortens the replicative life span of yeast cells undergoing division, does not shorten the chronological life span of G0-arrested cells.
12788479 Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells.
12297502 Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.
21931558 Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae.
16051752 HST2 mediates SIR2-independent life-span extension by calorie restriction.
17129213 Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.
22438832 The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex.
21949725 Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast.
15328540 Sir2-independent life span extension by calorie restriction in yeast.
16286010 Sir2 blocks extreme life-span extension.
22319457 Down-regulating sphingolipid synthesis increases yeast lifespan.
18513215 Caffeine extends yeast lifespan by targeting TORC1.
17711561 Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins.
21584246 Identification of potential calorie restriction-mimicking yeast mutants with increased mitochondrial respiratory chain and nitric oxide levels.
20640543 Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae.
18704665 Increased aerobic metabolism is essential for the beneficial effects of caloric restriction on yeast life span.
17403371 Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression.
16782871 Defective mitochondrial gene expression results in reactive oxygen species-mediated inhibition of respiration and reduction of yeast life span.
17460215 Effects of deleting mitochondrial antioxidant genes on life span.
20707985 Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genes.
16336970 Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence.
20713692 Yin and Yang of histone H2B roles in silencing and longevity: a tale of two arginines.
22216232 A network-based approach on elucidating the multi-faceted nature of chronological aging in S. cerevisiae.
16418483 Extension of chronological life span in yeast by decreased TOR pathway signaling.
19805817 Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response.
19424415 Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension.
18469137 Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span.
15722108 Genes determining yeast replicative life span in a long-lived genetic background.
21918615 Identification of longevity genes with systems biology approaches.
20421943 A microarray-based genetic screen for yeast chronological aging factors.
19458476 Autophagy is required for extension of yeast chronological life span by rapamycin.
21901113 Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.
22615903 Ammonium is toxic for aging yeast cells, inducing death and shortening of the chronological lifespan.
17544056 Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span.
11024000 An intervention resembling caloric restriction prolongs life span and retards aging in yeast.
22303396 Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan.
20622262 Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.
17710147 DNA replication stress is a determinant of chronological lifespan in budding yeast.
12855292 The Ras and Sch9 pathways regulate stress resistance and longevity.
18381895 The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast.
17200108 The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension.
20157595 Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density.
19467248 Inactivation of the 20S proteasome maturase, Ump1p, leads to the instability of mtDNA in Saccharomyces cerevisiae.
18195102 Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.
10620009 Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast.
18930829 The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease.
18628831 Genomic instability is associated with natural life span variation in Saccharomyces cerevisiae.
15020466 Rtg2 protein links metabolism and genome stability in yeast longevity.
15547318 The histone acetyltransferase GCN5 modulates the retrograde response and genome stability determining yeast longevity.
14729974 Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.
16741098 Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction".
21191185 Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast.
19305133 A molecular mechanism of chronological aging in yeast.
9851878 Role of RAS2 in recovery from chronic stress: effect on yeast life span.
21248481 Cell size and growth rate are major determinants of replicative lifespan.
12562756 Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing.
19303850 Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis.
22675632 Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60.
10430902 Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae.
1938877 Telomere length constancy during aging of Saccharomyces cerevisiae.
10207108 Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae.
7806576 Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span.
21482672 Mediator influences telomeric silencing and cellular life span.
2644196 Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae.
9275199 Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae.
19557187 Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae.
9789734 Epigenetic stratification: the role of individual change in the biological aging process.
11742528 Profiles of random change during aging contain hidden information about longevity and the aging process.
11389927 The DNA helicase activity of yeast Sgs1p is essential for normal lifespan but not for resistance to topoisomerase inhibitors.
12640455 Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan.
8647826 Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo.
9199172 Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast.
10222047 Mitochondrial superoxide decreases yeast survival in stationary phase.
12020810 Effect of superoxide dismutase deficiency on the life span of the yeast Saccharomyces cerevisiae. An oxygen-independent role of Cu,Zn-superoxide dismutase.
15621721 Ascorbate restores lifespan of superoxide-dismutase deficient yeast.
9620775 Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.
19570907 Budding yeast SSD1-V regulates transcript levels of many longevity genes and extends chronological life span in purified quiescent cells.
15126388 Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism.
21902802 Sir2 deletion prevents lifespan extension in 32 long-lived mutants.
21371425 GABA metabolism pathway genes, UGA1 and GAD1, regulate replicative lifespan in Saccharomyces cerevisiae.
20550517 Metabolomics-based systematic prediction of yeast lifespan and its application for semi-rational screening of ageing-related mutants.
21597195 Anti-aging effects of phloridzin, an apple polyphenol, on yeast via the SOD and Sir2 genes.
20093034 Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene.
15489200 A novel assay for replicative lifespan in Saccharomyces cerevisiae.
20729566 A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging.
21906795 Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction.
17492370 Mutations in the Atp1p and Atp3p subunits of yeast ATP synthase differentially affect respiration and fermentation in Saccharomyces cerevisiae.
16199065 Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae.
16023114 Yeast HAT1 and HAT2 deletions have different life-span and transcriptome phenotypes.
21707788 Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.
18162582 Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis.
22445853 Activation of the Hog1p kinase in Isc1p-deficient yeast cells is associated with mitochondrial dysfunction, oxidative stress sensitivity and premature aging.
16436509 Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging.
17174052 Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span.
16806052 MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria.
19059240 Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast.
18500447 Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast.
20799725 Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast.
19164565 A network biology approach to aging in yeast.
21931751 DAF-16 and Δ9 desaturase genes promote cold tolerance in long-lived Caenorhabditis elegans age-1 mutants.
19197346 Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.
18406553 Modulation of longevity and diapause by redox regulation mechanisms under the insulin-like signaling control in Caenorhabditis elegans.
20382831 Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage.
18073424 A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.
12470895 Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span.
22253756 Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans.
16293572 Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan, and causes lethality in a mitochondrial complex II mutant.
15771615 Reduced expression of frataxin extends the lifespan of Caenorhabditis elegans.
20172019 A role for p53 in mitochondrial stress response control of longevity in C. elegans.
19416129 p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress.
20346072 Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans.
19506556 A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.
16530050 Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling.
22505847 A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
21749634 The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
16563875 Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
17360327 A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.
21909281 The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.
18423931 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans.
19749979 A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans.
21423649 Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans.
20824162 The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling.
11381260 Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.
21713031 The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans.
21055415 Regulation of longevity by genes required for the functions of AIY interneuron in nematode Caenorhabditis elegans.
20332814 Genes required for the functions of olfactory AWA neuron regulate the longevity of Caenorhabditis elegans in an insulin/IGF signaling-dependent fashion.
17914900 Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans.
21884719 Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway.
20700440 RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.
22013497 Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans.
19061950 Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress.
19085685 Epigallocatechin gallate from green tea (Camellia sinensis) increases lifespan and stress resistance in Caenorhabditis elegans.
21858156 Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans.
14996832 Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans.
22452899 Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans.
19923212 The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunity.
17096597 p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.
21503726 Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans.
18024103 Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin.
18692520 Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?
18782349 The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans.
21695230 Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity.
18772467 Protein-repair and hormone-signaling pathways specify dauer and adult longevity and dauer development in Caenorhabditis elegans.
9353126 The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
20952811 Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans.
20590843 Redox regulation, gene expression and longevity.
21906946 Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans.
19469880 Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans.
17204841 Autophagy regulates ageing in C. elegans.
16626392 The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms.
15837805 Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression.
16626391 Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways.
17900900 An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.
19793063 Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway.
19489741 Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans.
17187771 Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans.
17538612 Two neurons mediate diet-restriction-induced longevity in C. elegans.
22303358 A narrow quantitative trait locus in C. elegans coordinately affects longevity, thermotolerance, and resistance to paraquat.
8934875 Defining genes that govern longevity in Caenorhabditis elegans.
8307318 Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci.
19764929 Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan.
19360094 Positive feedback between transcriptional and kinase suppression in nematodes with extraordinary longevity and stress resistance.
16300482 Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.
16164425 Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal.
17157356 Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal.
12618395 Genetic loci modulating fitness and life span in Caenorhabditis elegans: categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred worms.
21533182 Variable pathogenicity determines individual lifespan in Caenorhabditis elegans.
22156377 Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor.
16751106 A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.
15820683 JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling.
19279398 Autophagy genes mediate the effect of calcineurin on life span in C. elegans.
21331044 Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.
20550516 Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity.
19112515 Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans.
17711560 Caenorhabditis elegans integrates food and reproductive signals in lifespan determination.
21264793 The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans.
21932172 Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species.
22422488 L: -Theanine extends lifespan of adult Caenorhabditis elegans.
20925017 Differential effects of resveratrol and SRT1720 on lifespan of adult Caenorhabditis elegans.
20179756 Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways.
18033297 An antidepressant that extends lifespan in adult Caenorhabditis elegans.
18988854 Fat metabolism links germline stem cells and longevity in C. elegans.
21695191 The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans.
17187774 The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy.
22279556 Caenorhabditis elegans battling starvation stress: low levels of ethanol prolong lifespan in L1 larvae.
20209166 WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.
9434744 Targeted gene disruption of the Caenorhabditis elegans L-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes.
16280150 Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.
16777605 C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.
16256736 A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.
21938067 Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.
19597959 Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1.
20828537 Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16.
20528576 A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans.
18536978 Plant adaptogens increase lifespan and stress resistance in C. elegans.
21765926 Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms.
21614175 The lin-4 Gene Controls Fat Accumulation and Longevity in Caenorhabditis elegans.
18419309 Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains.
18006689 Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.
12690206 DAF-16 target genes that control C. elegans life-span and metabolism.
11909680 Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin.
17318365 Hormetic effects of repeated exposures to cold at young age on longevity, aging and resistance to heat or cold shocks in Drosophila melanogaster.
9183440 Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity.
11511092 Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans.
8700226 A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.
8608934 A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.
19580861 Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.
16826446 Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments.
18693219 The U-shaped response of initial mortality in Caenorhabditis elegans to mild heat shock: does it explain recent trends in human mortality?
11470134 Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans.
3385139 Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene.
2392681 Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging.
3473482 Aging can be genetically dissected into component processes using long-lived lines of Caenorhabditis elegans.
19747231 Mortality shifts in Caenorhabditis elegans: remembrance of conditions past.
11487591 Age-specific demographic profiles of longevity mutants in Caenorhabditis elegans show segmental effects.
21186286 A potential biochemical mechanism underlying the influence of sterol deprivation stress on Caenorhabditis elegans longevity.
21779524 High glucose diets shorten lifespan of Caenorhabditis elegans via ectopic apoptosis induction.
9725835 Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.
12480943 Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span.
14678010 Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans.
20862312 ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans.
18083317 Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes.
18457595 Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans.
12954481 Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans.
22577361 A role for SKN-1/Nrf in pathogen resistance and immunosenescence in Caenorhabditis elegans.
21533078 PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.
18241854 Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity.
20620993 EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity.
20178781 Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan.
17020605 Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling.
22185090 Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.
18836529 A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans.
19627265 Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1.
17339638 A demographic analysis of the fitness cost of extended longevity in Caenorhabditis elegans.
17521386 Longevity determined by developmental arrest genes in Caenorhabditis elegans.
17335870 The Caenorhabditis elegans nicotinamidase PNC-1 enhances survival.
6632998 A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results.
10708258 Isolating aging mutants: a novel method yields three strains of the nematode Caenorhabditis elegans with extended life spans.
8325483 Absence of strong heterosis for life span and other life history traits in Caenorhabditis elegans.
19662517 Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans.
926867 Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span.
18056973 Sex-specific effects of the DAF-12 steroid receptor on aging in Caenorhabditis elegans.
10819307 Defining wild-type life span in Caenorhabditis elegans.
16917064 Mutations that increase the life span of C. elegans inhibit tumor growth.
22360389 Temporal requirements of heat shock factor-1 for longevity assurance.
12750521 Regulation of aging and age-related disease by DAF-16 and heat-shock factor.
19467242 C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response.
11445592 Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans.
18538371 Repeated temperature fluctuation extends the life span of Caenorhabditis elegans in a daf-16-dependent fashion.
17895432 Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity.
18728385 The effects of p53 on whole organism longevity are mediated by autophagy.
20369008 Phenotypic covariance of longevity, immunity and stress resistance in the caenorhabditis nematodes.
17189267 Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans.
16373574 A developmental timing microRNA and its target regulate life span in C. elegans.
19713489 Starvation protects germline stem cells and extends reproductive longevity in C. elegans.
8169328 The effects of temperature on the longevity of a radiation-sensitive mutant rad-8 of the nematode Caenorhabditis elegans.
8350650 The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development.
7934213 Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans.
12620193 Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans.
15068796 C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.
10638523 The spe-10 mutant has longer life and increased stress resistance.
8807294 A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans.
16244463 Uncoupling of longevity and paraquat resistance in mutants of the nematode Caenorhabditis elegans.
16054097 C. elegans tubby regulates life span and fat storage by two independent mechanisms.
10377425 Neurosecretory control of aging in Caenorhabditis elegans.
11063684 Dauer formation induced by high temperatures in Caenorhabditis elegans.
17592521 Involvement of genes required for synaptic function in aging control in C. elegans.
10545213 Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster.
17934462 DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.
16673436 Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis.
22012258 Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.
20555324 Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans.
22570628 The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity.
21834846 The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner.
21803287 Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.
16380712 Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.
21129974 MicroRNAs both promote and antagonize longevity in C. elegans.
17276341 RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination.
19049972 Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.
17673661 Quantitative mass spectrometry identifies insulin signaling targets in C. elegans.
22792076 TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans.
8473689 Oxygen-dependent perturbation of life span and aging rate in the nematode.
18314552 Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans.
16377915 Lifespan extending activity of substances secreted by the nematode Caenorhabditis elegans that include the dauer-inducing pheromone.
21339330 Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
16099946 The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span.
20946987 TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenance.
8442664 Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster.
1379030 The effects of catalase gene overexpression on life span and resistance to oxidative stress in transgenic Drosophila melanogaster.
12521602 Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity.
15328413 An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster.
16026335 Calorie restriction delays lipid oxidative damage in Drosophila melanogaster.
16518700 Resistance to oxidative stress induced by paraquat correlates well with both decreased and increased lifespan in Drosophila melanogaster.
10995037 Oxidative stress resistance: a robust correlated response to selection in extended longevity lines of Drosophila melanogaster?
10638525 Stress resistance and longevity in selected lines of Drosophila melanogaster.
20686706 Quantitative and molecular genetic analyses of mutations increasing Drosophila life span.
15013662 Quantitative trait loci affecting natural variation in Drosophila longevity.
15379853 Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan.
11063689 Deficiency mapping of quantitative trait loci affecting longevity in Drosophila melanogaster.
16702433 High-resolution mapping of quantitative trait loci affecting increased life span in Drosophila melanogaster.
15834144 Survival analysis of life span quantitative trait loci in Drosophila melanogaster.
20003237 Identifying sexual differentiation genes that affect Drosophila life span.
20157509 A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila.
17349761 Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone.
15130751 Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span.
12072463 Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster.
21415465 Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogaster.
21108726 Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor.
19005568 Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs.
19385039 Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan.
17465980 Dynamics of the action of dFOXO on adult mortality in Drosophila.
18221413 Drosophila lifespan control by dietary restriction independent of insulin-like signaling.
20157574 Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.
19840842 Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects.
20838645 A naturally occurring polymorphism at Drosophila melanogaster Lim3 Locus, a homolog of human LHX3/4, affects Lim3 transcription and fly lifespan.
18053668 Interactions between injury, stress resistance, reproduction, and aging in Drosophila melanogaster.
11121683 Postponed aging and desiccation resistance in Drosophila melanogaster.
11430488 Genetic analysis of extended lifespan in Drosophila melanogaster III. On the relationship between artificially selected and wild stocks.
15466435 Longevity and metabolism in Drosophila melanogaster: genetic correlations between life span and age-specific metabolic rate in populations artificially selected for long life.
20435911 Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.
20089120 Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan.
20157575 The circadian clock gene period extends healthspan in aging Drosophila melanogaster.
22227001 Loss of circadian clock accelerates aging in neurodegeneration-prone mutants.
19428445 Neuronal susceptibility to GRIM in Drosophila melanogaster measures the rate of genetic changes that scale to lifespan.
18796296 The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila.
15491684 Doxycycline-regulated over-expression of hsp22 has negative effects on stress resistance and life span in adult Drosophila melanogaster.
19420297 Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions.
19720829 JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span.
22363408 Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila.
22291607 Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis.
20096722 Mitochondrial electron transport chain dysfunction during development does not extend lifespan in Drosophila melanogaster.
19798443 Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila.
17125951 Counting calories in Drosophila diet restriction.
16256171 Drosophila diet restriction in practice: do flies consume fewer nutrients?
19895881 Food presentation modifies longevity and the beneficial action of dietary restriction in Drosophila.
21518241 Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan.
21443682 dFOXO-independent effects of reduced insulin-like signaling in Drosophila.
20333234 Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk.
17874997 Dietary restriction alters demographic but not behavioral aging in Drosophila.
15288688 Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster.
11250117 Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster.
3113991 Successful selection for increased longevity in Drosophila: analysis of the survival data and presentation of a hypothesis on the genetic regulation of longevity.
15236760 Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity.
18268352 Lifespan and reproduction in Drosophila: New insights from nutritional geometry.
22042724 Balance between macronutrients affects life span and functional senescence in fruit fly Drosophila melanogaster.
15542350 Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster.
17709434 Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and lifespan and alters gene expression and histone biotinylation patterns.
17056793 Drosophila melanogaster holocarboxylase synthetase is a chromosomal protein required for normal histone biotinylation, gene transcription patterns, lifespan, and heat tolerance.
9226628 Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogaster.
19841272 Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan.
21406223 Nectarine promotes longevity in Drosophila melanogaster.
18245758 The effects of vitamin supplementation on Drosophila life span under normoxia and under oxidative stress.
19828196 Cerium caused life span shortening and oxidative stress resistance in Drosophila melanogaster.
19408653 [Changes of the life span and certain biochemical indexes on Drosophila melanogaster by ethanol exposure].
15547319 D-galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress.
19666103 Contrasted effects of suppressing live yeast from food on longevity, aging and resistance to several stresses in Drosophila melanogaster.
19823937 Combined effects of suppressing live yeast and of a cold pretreatment on longevity, aging and resistance to several stresses in Drosophila melanogaster.
17266676 The functional costs and benefits of dietary restriction in Drosophila.
17921418 Optimization of dietary restriction protocols in Drosophila.
16300483 Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction.
12882356 The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homologue chico.
15659213 Drosophila longevity is not affected by heterochromatin-mediated gene silencing.
20453260 Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila.
15954861 Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila.
20600782 Conditional inactivation of MRG15 gene function limits survival during larval and adult stages of Drosophila melanogaster.
11454765 High-frequency generation of conditional mutations affecting Drosophila melanogaster development and life span.
20422037 Carbon dioxide sensing modulates lifespan and physiology in Drosophila.
15708981 Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.
8183891 Protein synthesis elongation factor EF-1 alpha expression and longevity in Drosophila melanogaster.
21376794 Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz.
18458334 Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila.
19409408 Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging.
20655917 The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO.
11113599 Targeted neuronal gene expression and longevity in Drosophila.
12456885 RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress.
10506576 Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hyperoxia but not normoxia.
17011021 Comparison between the effects of aging and hyperoxia on glutathione redox state and protein mixed disulfides in Drosophila melanogaster.
22570630 Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality.
14500985 Demography of dietary restriction and death in Drosophila.
20367621 Biomarkers of aging in Drosophila.
14677635 Juvenile diet restriction and the aging and reproduction of adult Drosophila melanogaster.
22197903 Blueberry extract prolongs lifespan of Drosophila melanogaster.
21319854 Apple polyphenols extend the mean lifespan of Drosophila melanogaster.
8987567 Microgravity effects on Drosophila melanogaster behavior and aging. Implications of the IML-2 experiment.
9363888 Chaperoning extended life.
18056421 Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila.
18216496 Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis.
18955126 Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity.
17368005 Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan.
17592126 Ceramide transfer protein function is essential for normal oxidative stress response and lifespan.
15331597 Decreased lifespan in the absence of expression of the mitochondrial small heat shock protein Hsp22 in Drosophila.
20112046 Role of Drosophila alkaline ceramidase (Dacer) in Drosophila development and longevity.
22771817 Fertility/longevity trade-offs under limiting-male conditions in mating populations of Caenorhabditis elegans.
16000018 Calories do not explain extension of life span by dietary restriction in Drosophila.
1712294 The ovo gene of Drosophila encodes a zinc finger protein required for female germ line development.
20080168 Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet.
22253967 Dietary calcium and dairy modulation of oxidative stress and mortality in aP2-agouti and wild-type mice.
21109196 Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration.
22461615 Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
19880816 Disruption of the mGsta4 gene increases life span of C57BL mice.
21079617 No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight.
15498882 Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction.
22028811 A mild impairment of mitochondrial electron transport has sex-specific effects on lifespan and aging in mice.
19717971 Cisd2 mediates mitochondrial integrity and life span in mammals.
21422498 RasGrf1 deficiency delays aging in mice.
19797661 Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
11606777 Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals.
19487311 Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span.
10638529 AlphaMUPA mice: a transgenic model for increased life span.
19776219 Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.
14679299 Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging.
7493016 Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase.
10089885 Longevity, stress response, and cancer in aging telomerase-deficient mice.
11331780 Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan.
15153176 Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer.
17923673 Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.
6608731 Effects of food restriction on aging: separation of food intake and adiposity.
17973971 Influence of cardiac-specific overexpression of insulin-like growth factor 1 on lifespan and aging-associated changes in cardiac intracellular Ca2+ homeostasis, protein damage and apoptotic protein expression.
16195414 Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.
22367546 The sirtuin SIRT6 regulates lifespan in male mice.
12692087 Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction.
18434714 Genetic suppression of GH-IGF-1 activity, combined with lifelong caloric restriction, prevents age-related renal damage and prolongs the life span in rats.
20072627 Synergistic and additive effects of epigallocatechin gallate and digitonin on Plasmodium sporozoite survival and motility.
19129143 Significant effects of Pgi genotype and body reserves on lifespan in the Glanville fritillary butterfly.
18761078 Protein accumulation underlying lifespan extension via ovariectomy in grasshoppers is consistent with the disposable soma hypothesis but is not due to dietary restriction.
21742024 Life-extending dietary restriction and ovariectomy result in similar feeding rates but different physiologic responses in grasshoppers.
19558564 Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni).
21904823 Protein:carbohydrate ratios explain life span patterns found in Queensland fruit fly on diets varying in yeast:sugar ratios.
22094291 Additive and interactive effects of nutrient classes on longevity, reproduction, and diet consumption in the Queensland fruit fly (Bactrocera tryoni).
20609276 Effect of adult chill treatments on recovery, longevity and flight ability of Queensland fruit fly, Bactrocera tryoni (Froggatt) (Diptera: Tephritidae).
19774093 Adult diet affects lifespan and reproduction of the fruit-feeding butterfly Charaxes fulvescens.
19716408 Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens.
18346215 Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradients.
19264118 The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly.
19906819 Prolongevity effects of an oregano and cranberry extract are diet dependent in the Mexican fruit fly (Anastrepha ludens).
21455602 Prolongevity effects of a botanical with oregano and cranberry extracts in Mexican fruit flies: examining interactions of diet restriction and age.
11121722 Prevention of flight activity prolongs the life span of the housefly, Musca domestica, and attenuates the age-associated oxidative damamge to specific mitochondrial proteins.
12031907 Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica.
22170153 Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan.
22156391 Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression.
19266076 Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast.
20075862 Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway.
22768380 Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.
22810224 Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans.
22824366 Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans.
22912585 Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes.
22783207 Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration.
15141092 Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging.
11410594 Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span.
20477758 Trehalose extends longevity in the nematode Caenorhabditis elegans.
22829775 Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways.
22844336 The Yang-Tonifying Herbal Medicine Cynomorium songaricum Extends Lifespan and Delays Aging in Drosophila.
22843669 D-chiro-Inositol and Pinitol Extend the Life * Span of Drosophila melanogaster.
22846641 Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz.
22754872 Lack of Ach1 CoA-Transferase Triggers Apoptosis and Decreases Chronological Lifespan in Yeast.
16182251 The budding yeast protein Chl1p has a role in transcriptional silencing, rDNA recombination, and aging.
22848679 NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast.
22737090 An engineering approach to extending lifespan in C. elegans.
18202391 Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity.
22359667 C. elegans VANG-1 modulates life span via insulin/IGF-1-like signaling.
17266678 A steroid hormone that extends the lifespan of Caenorhabditis elegans.
15767565 JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
20844315 Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans.
17023606 Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction.
19553937 A conserved ubiquitination pathway determines longevity in response to diet restriction.
18285659 Hyperoxia exposure induced hormesis decreases mitochondrial superoxide radical levels via Ins/IGF-1 signaling pathway in a long-lived age-1 mutant of Caenorhabditis elegans.
12882325 Testing an 'aging gene' in long-lived drosophila strains: increased longevity depends on sex and genetic background.
18067683 Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes.
22653599 Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan.
16055649 Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.
19851477 dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster.
19461873 HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans.
20923705 Expression of multiple copies of mitochondrially targeted catalase or genomic Mn superoxide dismutase transgenes does not extend the life span of Drosophila melanogaster.
12743125 Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster.
17103233 Superoxide dismutase activities in long-lived Drosophila melanogaster females: chico1 genotypes and dietary dilution.
21876806 Lifespan and glucose metabolism in insulin receptor mutant mice.
15292400 Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes.
16434470 Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila.
22997544 Overexpression of Fatty-Acid-β-Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster.
23121290 Modulation of Methuselah Expression Targeted to Drosophila Insulin-producing Cells Extends Life and Enhances Oxidative Stress Resistance.
12820979 Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone.
23133668 Extension of yeast chronological lifespan by methylamine.
17634576 The chronological life span of Saccharomyces cerevisiae.
5961480 The effect of mating status, sex and genotype on longevity in Drosophila melanogaster.
21593793 The propeptide of yeast cathepsin D inhibits programmed necrosis.
12814798 An in vitro model of caloric restriction.
21031036 A network perspective on metabolism and aging.
18366601 An integrative approach to characterize disease-specific pathways and their coordination: a case study in cancer.
21685098 A novel computational framework for simultaneous integration of multiple types of genomic data to identify microRNA-gene regulatory modules.
18793464 A structural approach for finding functional modules from large biological networks.
16339439 A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis.
15855409 Bayesian network analysis of signaling networks: a primer.
20824084 Community landscapes: an integrative approach to determine overlapping network module hierarchy, identify key nodes and predict network dynamics.
15616139 Comparative genomics of centrality and essentiality in three eukaryotic protein-interaction networks.
20470404 Construction of a large scale integrated map of macrophage pathogen recognition and effector systems.
17967053 Construction, visualisation, and clustering of transcription networks from microarray expression data.
19779549 Disease-aging network reveals significant roles of aging genes in connecting genetic diseases.
11976460 Evolutionary rate in the protein interaction network.
16839197 Evolutionary and physiological importance of hub proteins.
17510664 Exploring genetic interactions and networks with yeast.
21144022 Extending pathways and processes using molecular interaction networks to analyse cancer genome data.
18344981 Genetics of gene expression and its effect on disease.
22479173 "Guilt by association" is the exception rather than the rule in gene networks.
19816451 How to visually interpret biological data using networks.
20406493 Identification of responsive gene modules by network-based gene clustering and extending: application to inflammation and angiogenesis.
21471013 Inferring Boolean network structure via correlation.
20128910 Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging.
18552845 Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks.
20211003 Integrated cellular network of transcription regulations and protein-protein interactions.
20213321 Interaction networks as a tool to investigate the mechanisms of aging.
21163940 Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.
17116322 Longevity network: construction and implications.
21197659 Network biology: a direct approach to study biological function.
14735121 Network biology: understanding the cell's functional organization.
21370096 Network inference from time-dependent Omics data.
20562859 Network organization of the human autophagy system.
19798086 Network visualization and analysis of gene expression data using BioLayout Express(3D).
21637797 Pathway analysis of expression data: deciphering functional building blocks of complex diseases.
15306346 Protein networks, pleiotropy and the evolution of senescence.
19628854 Scale-free networks: a decade and beyond.
20101245 Systems analysis of EGF receptor signaling dynamics with microwestern arrays.
20805835 Advantages and limitations of current network inference methods.
22140454 BinTree seeking: a novel approach to mine both bi-sparse and cohesive modules in protein interaction networks.
20824468 Computational modeling in systems biology.
21186362 Efficient modeling, simulation and coarse-graining of biological complexity with NFsim.
10591225 From molecular to modular cell biology.
20733244 A fast hierarchical clustering algorithm for functional modules discovery in protein interaction networks.
21253555 Measuring the evolutionary rewiring of biological networks.
12538875 Modular organization of cellular networks.
22737063 Multiple genetic interaction experiments provide complementary information useful for gene function prediction.
18707557 Network legos: building blocks of cellular wiring diagrams.
21164525 Network medicine: a network-based approach to human disease.
21278724 New approaches to modeling complex biochemistry.
21226925 Systems biological approach on neurological disorders: a novel molecular connectivity to aging and psychiatric diseases.
18474861 Estimating the size of the human interactome.
20974969 DDS, 4,4'-diaminodiphenylsulfone, extends organismic lifespan.
22970296 Metabolic rate regulates L1 longevity in C. elegans.
19084552 Japan-Korea joint seminar: Asian aging core for longevity 2008 in Nagasaki - toward the establishment of an Asian aging research and education center - September 4th to 6th, 2008 at Huis ten Bosch, Nagasaki, Japan.
23097426 Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans.
22482727 The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO.
23106705 GENOMIC BASIS OF AGING AND LIFE-HISTORY EVOLUTION IN DROSOPHILA MELANOGASTER.
16845399 Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways.
17353931 Large-scale mapping of human protein-protein interactions by mass spectrometry.
20607427 Flies selected for longevity retain a young gene expression profile.
11500818 A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity.
17196240 Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping.
12431377 Sequential activation of signaling pathways during innate immune responses in Drosophila.
16475980 Participation of a galactose-specific C-type lectin in Drosophila immunity.
18690243 Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function.
18776878 Live longer with LAMP-2.
19115216 Improve organ health by chewing up old proteins?
19481596 A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment.
11095759 Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.
15475297 graal: a Drosophila gene coding for several mosaic serine proteases.
16950154 A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.
20074316 Identification of a candidate adaptive polymorphism for Drosophila life history by parallel independent clines on two continents.
23167605 Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging.
23172144 An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.
23172930 Absence of Cardiotrophin 1 Is Associated With Decreased Age-Dependent Arterial Stiffness and Increased Longevity in Mice.
20732954 Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism.
23173729 A metabolic signature for long-life in the c. Elegans mit mutants.
17637672 Delayed ageing through damage protection by the Arf/p53 pathway.
21325617 Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.
23185716 Minocycline effect on life and health span of Drosophila melanogaster.
22107964 Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.
20816092 Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans.
17623811 Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster.
12399591 Timing requirements for insulin/IGF-1 signaling in C. elegans.
15192154 Long-lived Drosophila with overexpressed dFOXO in adult fat body.
17056719 Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant.
21810936 Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans.
21889502 The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis.
12725740 The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism.
20550518 Longevity is not influenced by prenatal programming of body size.
22498298 The prolongation of the lifespan of rats by repeated oral administration of fullerene.
15451059 A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties.
17079053 A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice.
21637768 Polyhydroxy fullerenes (fullerols or fullerenols): beneficial effects on growth and lifespan in diverse biological models.
21787853 Time-dependent variation in the biodistribution of C₆₀ in rats determined by liquid chromatography-tandem mass spectrometry.
16351219 fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity.
11905662 Olive-oil consumption and health: the possible role of antioxidants.
19369055 Dietary extra-virgin olive oil rich in phenolic antioxidants and the aging process: long-term effects in the rat.
22844398 Novel microRNAs differentially expressed during aging in the mouse brain.
16842496 Modulated microRNA expression during adult lifespan in Caenorhabditis elegans.
23075628 Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.
15115755 A Werner syndrome protein homolog affects C. elegans development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint.
12707040 Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice.
19741171 Vitamin C restores healthy aging in a mouse model for Werner syndrome.
23139829 Reduction of Type IV Collagen by Upregulated miR-29 in Normal Elderly Mouse and klotho-Deficient, Senescence-Model Mouse.
16125352 Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
18728386 Metformin slows down aging and extends life span of female SHR mice.
20090912 Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.
21386129 If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.
16224592 Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice.
21164223 Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice.
20304770 Metformin supplementation and life span in Fischer-344 rats.
23077661 Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila.
15754958 [Effect of antidiabetic drug diabenol on parameters of biological age, life span and tumor development in NMRI and HER-2/neu mice].
23177740 Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates.
15778722 Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.
20514327 Skin aging and photoaging alter fatty acids composition, including 11,14,17-eicosatrienoic acid, in the epidermis of human skin.
22253771 Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice.
21408016 Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice.
20070857 Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork.
16054100 Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.
18662546 SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
19833968 AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation.
17360649 Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation.
14612524 A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells.
23217706 The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism.
16439206 Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
17159295 Involvement of Drosophila Sir2-like genes in the regulation of life span.
22935001 Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain.
23041385 Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging.
23242215 Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
15475955 Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.
17272762 Aging-associated vascular phenotype in mutant mice with low levels of BubR1.
16781018 Mutant mice with small amounts of BubR1 display accelerated age-related gliosis.
18516091 Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency.
16411201 Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome.
20651707 Progeria syndromes and ageing: what is the connection?
21886162 The ageing systemic milieu negatively regulates neurogenesis and cognitive function.
15716955 Rejuvenation of aged progenitor cells by exposure to a young systemic environment.
10568741 Functional genomics and rat models.
15190254 Gene regulation and DNA damage in the ageing human brain.
23082321 A calorie-restricted diet decreases brain iron accumulation and preserves motor performance in old rhesus monkeys.
20541839 Effects of aging and calorie restriction on white matter in rhesus macaques.
19171901 Caloric restriction improves memory in elderly humans.
18486188 Dietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life span.
17555985 Dietary histone deacetylase inhibitors: from cells to mice to man.
12548552 Alpha-lipoic acid induces p27Kip-dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines.
8309958 The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits.
15627516 Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders.
12087131 Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior.
11602326 Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway.
23201549 Recent advances in calorie restriction research on aging.
19664690 Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
22555619 Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome.
15885745 Overview of caloric restriction and ageing.
22570137 Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice.
19648977 SASPense and DDRama in cancer and ageing.
23258410 Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity.
23251396 Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing.
23223368 Pigment-Dispersing Factor Is Involved in Age-Dependent Rhythm Changes in Drosophila melanogaster.
21482780 Serum factors in older individuals change cellular clock properties.
9791064 Later endogenous circadian temperature nadir relative to an earlier wake time in older people.
10198570 Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people.
19557547 Circadian clock resetting in the mouse changes with age.
10841208 Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep.
23064748 Linking the signaling cascades and dynamic regulatory networks controlling stress responses.
20450879 Regulation of SIRT1 in cellular functions: role of polyphenols.
21187328 SIRT1 contributes to telomere maintenance and augments global homologous recombination.
23239738 A steroid receptor-microRNA switch regulates life span in response to signals from the gonad.
23247094 Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans.
23271974 The GATA Transcription Factor egl-27 Delays Aging by Promoting Stress Resistance in Caenorhabditis elegans.
23273894 The longevity of sirtuins.
23246004 dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner.
9972869 Prolongation of life in an experimental model of aging in Drosophila melanogaster.
6334792 Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice.
17227869 Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
16847346 Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock.
5723482 Free radical theory of aging: effect of free radical reaction inhibitors on the mortality rate of male LAF mice.
2394907 Dietary restriction alone and in combination with oral ethoxyquin/2-mercaptoethylamine in mice.
11795501 Aging: overview.
8843194 Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.
8917548 Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
12540856 Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
8689683 Atm-deficient mice: a paradigm of ataxia telangiectasia.
19620979 A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.
18371340 Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.
17360389 Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice.
17420720 Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.
12533509 Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.
16476774 Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.
17188333 Caspase-2 deficiency enhances aging-related traits in mice.
16144468 Oxidative stress and aging: catalase is a longevity determinant enzyme.
14690422 Caveolin-1 null (-/-) mice show dramatic reductions in life span.
17143283 Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.
20231440 Lack of p21 expression links cell cycle control and appendage regeneration in mice.
21722344 The role of p21 in regulating mammalian regeneration.
16675955 ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.
17872905 Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice.
11950998 Premature aging in mice deficient in DNA repair and transcription.
17183314 A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.
16436465 Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process.
18729070 Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23.
14647066 Growth hormone stimulates proliferation of old-aged regenerating liver through forkhead box m1b.
16278235 Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.
22012613 Upregulation of TRB2 induced by miR-98 in the early lesions of large artery of type-2 diabetic rat.
16766679 Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes.
23283341 DRD4 Genotype Predicts Longevity in Mouse and Human.
18846204 Analysis of gene regulatory networks in the mammalian circadian rhythm.
21424790 Review of the literature and suggestions for the design of rodent survival studies for the identification of compounds that increase health and life span.
23235143 Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae.
22871733 pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast.
16784770 Preadaptation to efficient respiratory maintenance is essential both for maximal longevity and the retention of replicative potential in chronologically ageing yeast.
17506834 Mutations in the RAD27 and SGS1 genes differentially affect the chronological and replicative lifespan of yeast cells growing on glucose and glycerol.
23291976 Mechanism underlying prolongevity induced by bifidobacteria in Caenorhabditis elegans.
23291977 Sesamin extends the mean lifespan of fruit flies.
16441844 Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans.
11021802 Regulation of C. elegans life-span by insulinlike signaling in the nervous system.
23300685 Anti-Inflammatory Lactobacillus rhamnosus CNCM I-3690 Strain Protects against Oxidative Stress and Increases Lifespan in Caenorhabditis elegans.
23300461 Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation.
22768836 Replicative and chronological aging in Saccharomyces cerevisiae.
17188399 Breast cancer detection by Michaelis-Menten constants via linear programming.
18061365 The information-theory analysis of Michaelis-Menten constants for detection of breast cancer.
19231022 Comparative analysis of cell parameter groups for breast cancer detection.
23318230 HDL-is it too big to fail?
23286790 Genome-wide linkage analysis for human longevity: Genetics of Healthy Ageing Study.
18690365 An information-theoretical model for breast cancer detection.
21766191 Metabolic rate and membrane fatty acid composition in birds: a comparison between long-living parrots and short-living fowl.
20159547 Pathology of aging psittacines.
10631878 8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging.
11682567 Exceptional cellular resistance to oxidative damage in long-lived birds requires active gene expression.
17505961 Theories of ageing.
12882406 Involvement of the INK4a/Arf gene locus in senescence.
15520862 Ink4a/Arf expression is a biomarker of aging.
11544530 Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.
2901497 Fatality from illicit phendimetrazine use.
22265401 Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock.
22373043 Federated ontology-based queries over cancer data.
19796399 Semantic web data warehousing for caGrid.
23034122 Aging effects on DNA methylation modules in human brain and blood tissue.
23349740 Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.
16802111 Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions.
23325575 Curcumin and aging.
17516143 The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice.
23339066 MicroRNAs in age-related diseases.
21215371 The cell-non-autonomous nature of electron transport chain-mediated longevity.
19698732 A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians.
22549493 Genetic variation and human longevity.
23354332 Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging.
23363784 Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.
23242337 [Reversal of aging and lifespan elongation : Current biomedical key publications and the implications for geriatrics.]
23293221 Resveratrol protects against age-associated infertility in mice.
22960591 Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri.
23104101 Seven sirtuins for seven deadly diseases of aging.
23105098 Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis.
23055713 Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease.
23023872 Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells.
22982350 Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice.
16370369 NO link between calorie restriction and mitochondria.
23297346 Hydrogen Sulfide: Next Potent Preventive and Therapeutic Agent in Aging and Age-associated Diseases.
21296648 The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation.
23360310 Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements.
23375372 SIRT3 Reverses Aging-Associated Degeneration.
23374345 Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity.
23389440 FOXO3A directs a protective autophagy program in haematopoietic stem cells.
23186989 1α,25-Dihydroxyvitamin D3 and Resolvin D1 Retune the Balance between Amyloid-β Phagocytosis and Inflammation in Alzheimer's Disease Patients.
22704502 Restoring stem cell function in aged tissues by direct reprogramming?
22621821 Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients.
23382853 Copy number variations in alternative splicing gene networks impact lifespan.
16148000 Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster.
20976250 Lifespan extension by preserving proliferative homeostasis in Drosophila.
18371447 MicroRNA regulation of cell lineages in mouse and human embryonic stem cells.
20017609 Pharmacological inhibition of phosphoinositide 3 and TOR kinases improves survival of Drosophila melanogaster.
23419844 Network science.
23028566 Gene expression and physiological changes of different populations of the long-lived bivalve Arctica islandica under low oxygen conditions.
12855290 Is turtle longevity linked to enhanced mechanisms for surviving brain anoxia and reoxygenation?
20716943 Forever young: mechanisms of natural anoxia tolerance and potential links to longevity.
18472304 Bio2RDF: towards a mashup to build bioinformatics knowledge systems.
23396101 Long-term dynamics of CA1 hippocampal place codes.
23426728 Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease.
22947849 Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review.
23077164 Humoral immune responses are maintained with age in a long-lived ectotherm, the red-eared slider turtle.
22808278 Telomeres, age and reproduction in a long-lived reptile.
23222666 Comparative biology: Looking for a master switch.
23468654 Roles of the Developmental Regulator unc-62/Homothorax in Limiting Longevity in Caenorhabditis elegans.
23245767 PTEN in cancer, metabolism, and aging.
23508239 A novel classification system for evolutionary aging theories.
21624158 HyQue: evaluating hypotheses using Semantic Web technologies.
19929850 Calling International Rescue: knowledge lost in literature and data landslide!
21748327 Application of information theory to feature selection in protein docking.
21226956 A data mining approach for classifying DNA repair genes into ageing-related or non-ageing-related.
18986374 The Human Ageing Genomic Resources: online databases and tools for biogerontologists.
23193293 Human Ageing Genomic Resources: integrated databases and tools for the biology and genetics of ageing.
23470454 Deep sequencing identifies circulating mouse miRNAs that are functionally implicated in manifestations of aging and responsive to calorie restriction.
20148189 MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8.
16564011 A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.
18493317 Replicative senescence of mesenchymal stem cells: a continuous and organized process.
15662416 Role of the proto-oncogene Pokemon in cellular transformation and ARF repression.
9529248 The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.
18596985 The proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescence.
17656095 p53-mediated activation of miRNA34 candidate tumor-suppressor genes.
17554337 A microRNA component of the p53 tumour suppressor network.
17875987 Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells.
18451145 Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.
21625215 microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer.
22071762 Ageing: Old cells under attack.
22358842 Maintenance of muscle stem-cell quiescence by microRNA-489.
19962668 miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.
20618998 MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN.
20437201 miR-17-92 cluster: ups and downs in cancer and aging.
20089119 miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging.
22817539 Testing predictions of the programmed and stochastic theories of aging: comparison of variation in age at death, menopause, and sexual maturation.
19878148 MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging.
21216258 Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1.
20708718 MicroRNA and aging: a novel modulator in regulating the aging network.
22294612 MicroRNAs and their roles in aging.
23165099 The emergence of Semantic Systems Biology.
18561983 Murine microRNAs implicated in liver functions and aging process.
23636330 Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH.
21949706 Change and aging senescence as an adaptation.
23633914 MicroRNA in Aging: From Discovery to Biology.
23513468 The expression of Per1 and Aa-nat genes in the pineal gland of postnatal rats.
20647238 MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain.
10626278 Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms.
11404047 The programmed death phenomena, aging, and the Samurai law of biology.
6245013 Stress and mortality in a small marsupial (Antechinus stuartii, Macleay).
9467841 Aging is a specific biological function rather than the result of a disorder in complex living systems: biochemical evidence in support of Weismann's hypothesis.
10648966 Phenoptosis: programmed death of an organism.
9823889 Cell suicide for beginners.
10974124 Programmed death in bacteria.
11316611 The Ste20 group kinases as regulators of MAP kinase cascades.
14962645 Aging as an evolved characteristic - Weismann's theory reconsidered.
21076182 The sweet taste of death: glucose triggers apoptosis during yeast chronological aging.
15452146 Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae.
22932268 Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study.
15177050 How bioinformatics can help reverse engineer human aging.
5327241 Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process.
23648059 Prolonged Lifespan with Enhanced Exploratory Behavior in Mice Overexpressing the Oxidized Nucleoside Triphosphatase hMTH1.
12610294 The endocrine regulation of aging by insulin-like signals.
12391301 Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy.
16055719 The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster.
14570233 Delayed behavioural aging and altered mortality in Drosophila beta integrin mutants.
17686972 Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling.
16713954 Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function.
17854771 A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in Drosophila.
2539600 Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.
15133470 The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila.
16172499 Post-transcriptional silencing and functional characterization of the Drosophila melanogaster homolog of human Surf1.
16054055 Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.
18665908 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila.
19302370 Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans.
17999718 Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion.
18221418 Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype.
20018689 Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.
20589912 Life-span phenotypes of elav and Rbp9 in Drosophila suggest functional cooperation of the two ELAV-family protein genes.
18258192 Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila.
19011900 Adult-specific over-expression of the Drosophila genes magu and hebe increases life span and modulates late-age female fecundity.
19948727 Proproliferative functions of Drosophila small mitochondrial heat shock protein 22 in human cells.
15346199 Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression.
18275960 Overexpression of Drosophila juvenile hormone esterase binding protein results in anti-JH effects and reduced pheromone abundance.
21029723 dGIPC is required for the locomotive activity and longevity in Drosophila.
18494863 The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies.
21776417 Loco signaling pathway in longevity.
18208580 Acquired temperature-sensitive paralysis as a biomarker of declining neuronal function in aging Drosophila.
18083727 The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function.
18775584 Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity.
18678867 Life span extension and neuronal cell protection by Drosophila nicotinamidase.
21826223 Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.
21111239 FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging.
18478054 An RGS-containing sorting nexin controls Drosophila lifespan.
20622267 Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout.
19209226 Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.
18809674 Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster.
15695762 Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors.
22055505 Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.
23669073 Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan.
12434020 Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia.
16166262 miR-15 and miR-16 induce apoptosis by targeting BCL2.
21532615 Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer.
15648093 miR-15a and miR-16-1 down-regulation in pituitary adenomas.
17827156 Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells.
19391107 Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway.
23390502 MicroRNA-145 is downregulated in glial tumors and regulates glioma cell migration by targeting connective tissue growth factor.
23577178 Functional Profiling of Precursor MicroRNAs Identifies MicroRNAs Essential for Glioma Proliferation.
17540599 Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis.
17554199 Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest.
18505919 A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene.
12634288 Distributions of ACE and APOE polymorphisms and their relations with dementia status in Korean centenarians.
12601526 Deficiency of choresteryl ester transfer protein and gene polymorphisms of lipoprotein lipase and hepatic lipase are not associated with longevity.
23213392 Influences of lamin A levels on induction of pluripotent stem cells.
21558242 The heat dissipation limit theory and evolution of life histories in endotherms--time to dispose of the disposable soma theory?
22884974 Senescence in natural populations of animals: widespread evidence and its implications for bio-gerontology.
20228939 Effect of feeding regimens on circadian rhythms: implications for aging and longevity.
21376793 Long-lived mice exhibit 24 h locomotor circadian rhythms at young and old age.
20580916 Chronobiological aspects of nutrition, metabolic syndrome and obesity.
21402069 Calorie restriction and prevention of age-associated chronic disease.
21981968 Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings.
20395504 Extending healthy life span--from yeast to humans.
22608008 Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.
22593546 Timed high-fat diet resets circadian metabolism and prevents obesity.
23050095 Meal frequency patterns determine the phase of mouse peripheral circadian clocks.
22217096 Effects of aging on the molecular circadian oscillations in Drosophila.
22395806 The circadian clock and pathology of the ageing brain.
21454295 Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta.
12149444 Effects of aging on central and peripheral mammalian clocks.
22268765 Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations.
22705307 Daily profile in two circadian markers "melatonin and cortisol" and associations with metabolic syndrome components.
22672634 Evidence of the receptor-mediated influence of melatonin on pancreatic glucagon secretion via the Gαq protein-coupled and PI3K signaling pathways.
19854863 Metabolism and circadian rhythms--implications for obesity.
23691220 Dietary Restriction Depends on Nutrient Composition to Extend Chronological Lifespan in Budding Yeast Saccharomyces cerevisiae.
23698443 Mitonuclear protein imbalance as a conserved longevity mechanism.
19182541 Dissecting the genetics of longevity in Drosophila melanogaster.
18707322 Negligible Senescence during Reproductive Dormancy in Drosophila melanogaster.
17043223 Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase.
11039916 The effect of different light regimes on adult life span in Drosophila melanogaster is partly mediated through reproductive output.
20809749 Lentiviral vector-mediated upregulation of let-7a inhibits gastric carcinoma cell growth in vitro and in vivo.
21349817 Low-level expression of let-7a in gastric cancer and its involvement in tumorigenesis by targeting RAB40C.
23339187 The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancer.
23335963 Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein.
22918121 Suppression of the let-7b microRNA pathway by DNA hypermethylation in infant acute lymphoblastic leukemia with MLL gene rearrangements.
18379589 MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth.
22479342 MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth.
22128178 MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells.
21574070 Voting with their mice: personal genome testing and the "participatory turn" in disease research.
22090473 Genome-environment interactions that modulate aging: powerful targets for drug discovery.
22327899 A meta-analysis of caloric restriction gene expression profiles to infer common signatures and regulatory mechanisms.
23098078 The role of DNA methylation in aging, rejuvenation, and age-related disease.
22533440 Accelerated aging versus rejuvenation of the immune system in heterochronic parabiosis.
12386342 A test of evolutionary theories of aging.
6776406 A test of evolutionary theories of senescence.
19465083 Extreme-longevity mutations orchestrate silencing of multiple signaling pathways.
21740922 A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals.
21994419 MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer.
21709669 MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B.
21205300 MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation.
23171948 miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKα1.
23318422 MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine.
21971665 Altered expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation.
16799135 A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity.
11780357 Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang.
15547317 Single nucleotide polymorphisms: aging and diseases.
8018664 Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians.
11193221 Age-associated accumulation of the apolipoprotein C-III gene T-455C polymorphism C allele in a Russian population.
16602826 Lipoprotein genotype and conserved pathway for exceptional longevity in humans.
17148178 The longevity of Caenorhabditis elegans in soil.
9849895 Longevity of lobsters is linked to ubiquitous telomerase expression.
9742964 Telomerase activity in 'immortal' fish.
19415983 Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study.
23389097 The Frequency of 4 Common Gene Polymorphisms in Nonagenarians, Centenarians, and Average Life Span Individuals.
14499494 Polymorphisms in the human homologue of the drosophila Indy (I'm not dead yet) gene.
17027907 Serum heat shock protein 70 level as a biomarker of exceptional longevity.
16399887 Genetic contribution to aging: deleterious and helpful genes define life expectancy.
22506048 A genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional loci.
20518833 Association of longevity with IL-10 -1082 G/A and TNF-alpha-308 G/A polymorphisms.
19881466 Human chitotriosidase polymorphism is associated with human longevity in Mediterranean nonagenarians and centenarians.
21432114 Genetic epidemiological studies of longevity-associated mitochondrial DNA 5178 C/A polymorphism.
22351285 Immunogenetics and Life-Span : HLA.
16387839 Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population.
14667147 Noncircadian regulation and function of clock genes period and timeless in oogenesis of Drosophila melanogaster.
9610775 Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia.
15243211 CETP gene variation: relation to lipid parameters and cardiovascular risk.
7628082 Apolipoprotein E: an important gene and protein to follow in laboratory medicine.
3479440 Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E.
1998654 Effects of the apolipoprotein E polymorphism on levels of lipids, lipoproteins, and apolipoproteins among Mexican-Americans in Starr County, Texas.
3277611 Apolipoprotein E polymorphism and atherosclerosis.
8696954 Apolipoprotein E polymorphism in American Indians and its relation to plasma lipoproteins and diabetes. The Strong Heart Study.
8018666 Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study.
1867194 The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations.
3698268 Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease.
11882522 Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review.
16799145 Association between serum beta-carotene levels and decline of cognitive function in high-functioning older persons with or without apolipoprotein E 4 alleles: MacArthur studies of successful aging.
16803999 Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4.
9887369 Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2).
15105583 Assessing genetic association with human survival at multi-allelic loci.
15820493 Pilot study of arbitrarily primed PCR-single stranded DNA conformation polymorphism analysis for screening genetic polymorphisms related to specific phenotypes.
10496068 Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins.
9761238 Plasma concentration, kinetic constants, and gene polymorphism of angiotensin I-converting enzyme in centenarians.
11773214 Angiotensin-converting enzyme gene and longevity in the Xin Jiang Uighur autonomous region of China: an association study.
11602206 Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity.
12556235 The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects.
9622284 In search of a biological pattern for human longevity: impact of apo A-IV genetic polymorphisms on lipoproteins and the hyper-Lp(a) in centenarians.
9050915 DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus.
12646697 Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism.
15939070 Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study.
11162685 Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: difference at GSTT1 locus.
11857056 Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population.
9389323 Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity.
12566526 Relationship between microsatellite polymorphism in the haem oxygenase-1 gene promoter and longevity of the normal Japanese population.
14501185 The allele (A)(-110) in the promoter region of the HSP70-1 gene is unfavorable to longevity in women.
16804002 Heat-shock protein 70 genes and human longevity: a view from Denmark.
12742533 Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population.
11772518 Allele frequencies of +874T-->A single nucleotide polymorphism at the first intron of interferon-gamma gene in a group of Italian centenarians.
12843179 Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control.
11857058 Gender-specific association between -1082 IL-10 promoter polymorphism and longevity.
15582274 Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways.
16474933 Association between the MLH1 gene and longevity.
16142417 The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity.
12889841 Effect of six candidate genes on early aging in a French population.
15236769 Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity.
16095668 Contribution of an affect-associated gene to human longevity: prevalence of the long-allele genotype of the serotonin transporter-linked gene in Japanese centenarians.
15569360 The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians.
16269080 Human leukocyte antigen class I, class II, and tumor necrosis factor-alpha polymorphisms in a healthy elder Mexican Mestizo population.
20569235 HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.
23695394 A Dwarf Mouse Model With Decreased GH/IGF-1 Activity That Does Not Experience Life-Span Extension: Potential Impact of Increased Adiposity, Leptin, and Insulin With Advancing Age.
23236401 MiR-27a functions as a tumor suppressor in acute leukemia by regulating 14-3-3θ.
18789835 MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin.
22628407 miR-23a promotes the transition from indolent to invasive colorectal cancer.
18719391 Mechanisms of microRNA deregulation in human cancer.
2035418 Advances in the concepts of intensive care.
22996741 MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression.
22027551 Recycling, clustering, and endocytosis jointly maintain PIN auxin carrier polarity at the plasma membrane.
20354188 MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene.
22027557 Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells.
22700217 Dynamics of olfactory and hippocampal neurogenesis in adult sheep.
12882410 Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice.
23125046 TP53*P72 allele influences negatively female life expectancy in a population of central Italy: cross-sectional study and genetic-demographic approach analysis.
11772517 The -174 C/G locus affects in vitro/in vivo IL-6 production during aging.
15466015 Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease.
19367319 Human longevity and 11p15.5: a study in 1321 centenarians.
21299522 'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop.
11053677 Common gene variants, mortality and extreme longevity in humans.
9425225 HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity.
12044933 Fixation of deleterious alleles, evolution and human aging.
12954489 Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: different allele frequencies between the North and South of Europe.
16804001 Reduced expression levels of the senescence biomarker clusterin/apolipoprotein j in lymphocytes from healthy centenarians.
22960875 Ataxia-telangiectasia mutated (ATM) genetic variant in Italian centenarians.
15177664 Polymorphic metabolic susceptibility genes and longevity: a study in octogonarians.
3632129 Polymorphism of heterochromatin areas on chromosomes 1, 9, 16 and Y in long-lived subjects and persons of different ages in two regions of the Soviet Union.
22303384 Whole genome sequences of a male and female supercentenarian, ages greater than 114 years.
17493663 Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men.
10744171 The contribution of factor VII gene polymorphisms to longevity in Scottish nonagenarians.
20426625 HLA and KIR frequencies in Sicilian Centenarians.
15050300 Immunological markers contributing to successful aging in Bulgarians.
22336474 Cholesteryl ester transfer protein TaqIB polymorphism and its association with serum lipid levels and longevity in Chinese Bama Zhuang population.
20720309 An age-related decrease in factor V Leiden frequency among Polish subjects.
18756013 Power for genetic association study of human longevity using the case-control design.
21798861 Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.
18545700 Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan.
16257164 Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity.
17445222 14th International HLA and Immunogenetics Workshop: report on the immunogenetics of aging.
19249341 Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.
12547486 Angiotensin I-converting enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival--a follow-up study of elderly Danish twins.
22113349 Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.
15621216 Biological evidence for inheritance of exceptional longevity.
23273182 Microsomal triglyceride transfer protein gene -493G/T polymorphism and its association with serum lipid levels in Bama Zhuang long-living families in China.
16518718 Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity.
22456784 The Alu polymorphism of angiotensin I converting enzyme (ACE) and atherosclerosis, incident chronic diseases and mortality in an elderly Chinese population.
19763607 Gene variants as determinants of longevity: focus on the inflammatory factors.
20834067 Joint influence of small-effect genetic variants on human longevity.
17393087 Correlation between haplotype of apolipoprotein B gene and natural longevity persons in Uygur nationality.
18341427 Genetic polymorphisms and human aging: association studies deliver.
23376243 Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing.
21388494 Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans.
10219002 C4, BF, C3 allele distribution and complement activity in healthy aged people and centenarians.
14530863 Association analysis of the SHC1 gene locus with longevity in the Japanese population.
15664628 Interleukin-6 -174G/C polymorphism and longevity: a follow-up study.
22773346 Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
17934638 Apolipoprotein E polymorphism distribution in an elderly Brazilian population: the Bambuí Health and Aging Study.
23372024 The Epidemiology of Longevity and Exceptional Survival.
17506774 Interleukin 6 variable number of tandem repeats (VNTR) gene polymorphism in centenarians.
16405962 Impact of genetic variations in the WRN gene on age related pathologies and mortality.
21051524 Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals.
20388090 Anti-inflammatory heat shock protein 70 genes are positively associated with human survival.
19421891 The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect.
11788960 Mortality differences by APOE genotype estimated from demographic synthesis.
11485022 The plasminogen activator inhibitor 1 4G/5G polymorphism is not associated with longevity: a study in octogenarians.
21703254 APOE haplotypes are associated with human longevity in a Central Italy population: evidence for epistasis with HP 1/2 polymorphism.
21418511 Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
22722495 Osh6 links yeast vacuolar functions to lifespan extension and TOR.
23773067 Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here.
23704949 Extension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary Restriction.
23683827 Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation.
20505758 microRNA expression patterns reveal differential expression of target genes with age.
23644076 Microglia during development and aging.
15676284 A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.
11943467 An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.
11672987 Sex-specific longevity associations defined by Tyrosine Hydroxylase-Insulin-Insulin Growth Factor 2 haplotypes on the 11p15.5 chromosomal region.
11448941 Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males.
14580859 Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly.
12297342 The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene). A relative risk approach.
22465014 Over-expression of human clusterin increases stress resistance and extends lifespan in Drosophila melanogaster.
11015124 Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: apolipoprotein E gene is a "frailty gene," not a "longevity gene".
10463944 Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans.
15036421 Variation in the SHC1 gene and longevity in humans.
10996007 Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis.
18448515 Evidence that the gene encoding insulin degrading enzyme influences human lifespan.
22729909 Mitochondrial DNA polymorphisms are associated with the longevity in the Guangxi Bama population of China.
21424155 Role of prothrombotic polymorphisms in successful or unsuccessful aging.
20884733 Effects of FOXO genotypes on longevity: a biodemographic analysis.
16960022 Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy.
21113673 PTPN22 1858C>T (R620W) functional polymorphism and human longevity.
20230275 Preliminary evidence of a genetic association between chromosome 9p21.3 and human longevity.
10583447 Methylenetetrahydrofolate reductase polymorphism, plasma homocysteine and age.
15028112 A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians.
23354683 Association of the K153R polymorphism in the myostatin gene and extreme longevity.
15888337 Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians.
18511746 Adiponectin levels and genotype: a potential regulator of life span in humans.
16955215 Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population.
21726414 Immunogenetics of ageing.
11795532 BRCA1 gene sequence variation in centenarians.
19502260 Lack of genetic association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and longevity in a Han Chinese population.
10705035 Genetics of aging: lessons from centenarians.
15050299 Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis.
22234866 Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.
23128285 Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study.
17048073 Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity.
15130674 Hypothetical soluble KIR2DS4 natural killer cell receptor molecule does not associate with successful ageing in the Irish.
23186209 Mitochondriogenesis genes and extreme longevity.
10577935 P53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia.
11938442 A centenarian-only approach for assessing gene-gene interaction in human longevity.
21972126 Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity.
18458168 Mitochondrial haplogroups: ischemic cardiovascular disease, other diseases, mortality, and longevity in the general population.
12965974 Understanding the determinants of exceptional longevity.
16251894 Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study.
19245677 Gene expression profiles associated with aging and mortality in humans.
20003469 Association between SOD2 T-9C and MTHFR C677T polymorphisms and longevity: a study in Jordanian population.
22340368 Human longevity and common variations in the LMNA gene: a meta-analysis.
18256523 The common germline Arg72Pro polymorphism of p53 and increased longevity in humans.
21222045 The relationship between fertility and lifespan in humans.
17389728 Genetic variation and human aging: progress and prospects.
10069711 Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians.
20819792 Association of CYP19 and ESR1 pleiotropic genes with human longevity.
19377912 Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism.
17234815 Lower prevalence of epsilon 4 allele of apolipoprotein E gene in healthy, longer-lived individuals of Hellenic origin.
11772516 Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells.
20855428 Aging is accompanied by a progressive decrease of expression of the WRN gene in human blood mononuclear cells.
21332925 Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.
12483296 Mitochondrial DNA polymorphisms associated with longevity in a Finnish population.
22743239 UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.
17903295 Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.
11269751 Decreased longevity in Japanese men, associated with low-molecular-weight apolipoprotein(a) phenotypes.
22985157 Prevalence of the long-allele genotype of the serotonin transporter-linked gene in female centenarians.
11213279 Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study.
21340542 A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity.
15288696 Investigation of KIR diversity in immunosenescence and longevity within the Irish population.
20174870 Gender-specific association of ADA genetic polymorphism with human longevity.
21612516 Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins.
20434535 Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects.
18511747 A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism.
16424284 Association of interleukin-10 promoter single nucleotide polymorphisms -819 T/C and -592 A/C with aging.
22174011 Genomics of human health and aging.
12676903 Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP.
22496539 Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.
16893392 The FCGR2A--Arg131 variant is no major mortality factor in the elderly--evidence from a German centenarian study.
9147371 HLA and longevity or aging among Shanghai Chinese.
16518704 Study of the association with -330T/G IL-2 in a population of centenarians from centre and south Italy.
19887537 The IRS2 Gly1057Asp variant is associated with human longevity.
14528043 Angiotensin I-converting enzyme gene polymorphism in two ethnic groups living in Brazil's southern region: association with age.
21827845 Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity.
17261792 Role of proinflammatory alleles in longevity and atherosclerosis: results of studies performed on -1562C/T MMP-9 in centenarians and myocardial infarction patients from Sicily.
22406557 Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
16487435 Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians.
19489743 Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.
18759861 Mitochondrial DNA haplogroups in a Chinese Uygur population and their potential association with longevity.
20824210 High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci.
22569962 Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity.
17714903 Analysis of HLA-DRB1, DQA1, DQB1 haplotypes in Sardinian centenarians.
12714263 Association between the HFE mutations and longevity: a study in Sardinian population.
9106548 Methylenetetrahydrofolate reductase thermolabile variant and human longevity.
21262335 Absence of association between mitochondrial DNA C150T polymorphism and longevity in a Han Chinese population.
16015282 No evidence for an association between extreme longevity and microsomal transfer protein polymorphisms in a longitudinal study of 1651 nonagenarians.
11470126 Apolipoprotein E alleles in nonagenarian subjects in the Belfast Elderly Longitudinal Free-living Ageing Study (BELFAST).
12082503 Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians.
9654200 Lack of association between human longevity and genetic polymorphisms in drug-metabolizing enzymes at the NAT2, GSTM1 and CYP2D6 loci.
17452725 Liver X receptor alpha associates with human life span.
20816691 A functional single nucleotide polymorphism in promoter of ATM is associated with longevity.
20199671 A microsatellite polymorphism in IGF1 gene promoter and longevity in a Han Chinese population.
20582731 Variations in short tandem repeats deduced on the basis of the number of repeats and the relationship of these variations with longevity.
9587069 Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians.
16799134 Paraoxonase activity and genotype predispose to successful aging.
17339647 Absence of relationship between MTTP haplotypes and longevity.
21407269 Association of TH01 with human longevity revisited.
21945877 Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China.
12714268 HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish.
23133589 Bitter taste receptor polymorphisms and human aging.
16574194 A longitudinal study of the effect of GSTT1 and GSTM1 gene copy number on survival.
9792194 Apolipoprotein E and longevity among Han Chinese population.
18761080 Absence of association between SNPs in the promoter region of the insulin-like growth factor 1 (IGF-1) gene and longevity in the Han Chinese population.
19793722 Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.
21614448 Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans.
20599431 The -351A/G polymorphism of ESR1 is associated with risk of myocardial infarction but not with extreme longevity.
20126416 Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population.
22929028 AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians.
21750925 Mitochondrial haplogroup X is associated with successful aging in the Amish.
15771611 Reduced insulin/IGF-1 signalling and human longevity.
12714264 The role of IL-1 gene cluster in longevity: a study in Italian population.
22445811 Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS).
21330423 Is the ACE I/D polymorphism associated with extreme longevity? A study on a Spanish cohort.
18931934 Association of mitochondrial haplogroup J and mtDNA oxidative damage in two different North Spain elderly populations.
11640949 Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians.
19707883 Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity.
22156437 Discovery of functional gene variants associated with human longevity: opportunities and challenges.
12581796 Association between the HLA-DR alleles and longevity: a study in Sardinian population.
15621218 Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians.
21147083 Haptoglobin (HP) polymorphisms and human longevity: A cross-sectional association study in a Central Italy population.
19840767 Interactive association of heat shock protein 70 genes variants with natural longevity in Xinjiang Hetian Uygur ethnicity.
23339001 Total and high molecular weight adiponectin and level-modifying polymorphisms of ADIPOQ in centenarians.
6240576 Genetic study of high longevity index populations.
7089955 HLA and longevity.
9533408 Apolipoprotein AIV codon 360 mutation increases with human aging and is not associated with Alzheimer's disease.
9585593 A model for antagonistic pleiotropic gene action for mortality and advanced age.
9754988 Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevitY. Role of CYP2D6 and CYP2C19 in longevity.
9759473 Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts.
9854023 Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations.
10643896 Decreased frequency of apolipoprotein E epsilon4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians.
11053670 Does a retrograde response in human aging and longevity exist?
11280044 A study of French centenarians: are ACE and APOE associated with longevity?
11292511 Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data.
11404057 Mitochondrial DNA polymorphism: its role in longevity of the Irish population.
11592926 Replication studies in longevity: puzzling findings in Danish centenarians at the 3'APOB-VNTR locus.
11965496 Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: studies on centenarians.
12076681 The genetics of aging.
12384792 Mitochondrial DNA 5178A polymorphism and longevity.
15130757 Modest implication of interleukin-6 promoter polymorphisms in longevity.
15195682 Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls.
15236771 Interleukin 6-174 G/C promoter gene polymorphism in centenarians: no evidence of association with human longevity or interaction with apolipoprotein E alleles.
15241482 Paraoxonase 1 polymorphisms and survival.
15472150 The catalase -262C/T promoter polymorphism and aging phenotypes.
15621217 Exploring the genetics of longevity in the Old Order Amish.
15677572 Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity.
15720298 Haplotype effects on human survival: logistic regression models applied to unphased genotype data.
16803995 The genetics of human longevity.
16848980 Genome-wide approaches to understanding human ageing.
17077204 Glucose-6-phosphate dehydrogenase deficiency in female octogenarians, nanogenarians, and centenarians.
17090420 Genes, ageing and longevity in humans: problems, advantages and perspectives.
17331249 SOD2 polymorphisms: unmasking the effect of polymorphism on splicing.
17364902 Molecular genetic studies on relationships among longevity, diseases, and HLA-DRB1/DQB1 allelic polymorphism.
17574707 Role of VEGF gene variability in longevity: a lesson from the Italian population.
17784782 Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging.
17869046 Hemostasis factors and aging.
17989723 A novel sampling design to explore gene-longevity associations: the ECHA study.
18379014 Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity.
18510744 Sequencing and genotypic analysis of the triosephosphate isomerase (TPI1) locus in a large sample of long-lived Germans.
18765803 FOXO3A genotype is strongly associated with human longevity.
19000922 Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study.
19196970 Association of FOXO3A variation with human longevity confirmed in German centenarians.
19428448 The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old.
19459036 TLR4 polymorphisms and ageing: implications for the pathophysiology of age-related diseases.
19641616 Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.
20003397 The neck-region polymorphism of DC-SIGNR in peri-centenarian from Han Chinese population.
20011587 RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.
20201642 Associations of polymorphisms in adiponectin and leptin genes with men's longevity.
20362697 No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis.
20407924 Tagging long-lived individuals through vitamin-D receptor (VDR) haplotypes.
20549353 Inflammation, genetic background and longevity.
20595579 Genetic signatures of exceptional longevity in humans.
20633545 SIRT1 variants are associated with aging in a healthy Han Chinese population.
20800603 Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
20849522 Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data.
21115528 Genomics of human longevity.
21407828 Are 'endurance' alleles 'survival' alleles? Insights from the ACTN3 R577X polymorphism.
21503725 Zinc, metallothioneins and immunosenescence: effect of zinc supply as nutrigenomic approach.
21865054 Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancy.
22136229 Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis.
22265023 Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals.
22524405 The application of genetics approaches to the study of exceptional longevity in humans: potential and limitations.
22912757 Evaluation of the role of SNCA variants in survival without neurological disease.
22985084 Gender-specific association between FSHR and PPARG common variants and human longevity.
23020224 Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.
23162014 Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults.
19641380 Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans.
22533364 Polygenic effects of common single-nucleotide polymorphisms on life span: when association meets causality.
14615589 Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan.
11282420 Biological and clinical implications of the MTHFR C677T polymorphism.
19027825 Genetic polymorphism in long-lived people: cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity.
23040522 Apolipoprotein E and familial longevity.
16896546 Genes and longevity: a genetic-demographic approach reveals sex- and age-specific gene effects not shown by the case-control approach (APOE and HSP70.1 loci).
12855277 Genetics of exceptional longevity.
16608414 Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians.
18834923 Variation in NPC1, the gene encoding Niemann-Pick C1, a protein involved in intracellular cholesterol transport, is associated with Alzheimer disease and/or aging in the Polish population.
21115529 Genetics and genomics of human ageing.
16970956 Connexin37 1019 gene polymorphism in myocardial infarction patients and centenarians.
21782286 A genome-wide association study of aging.
18034366 Lack of replication of genetic associations with human longevity.
22607627 How genes influence life span: the biodemography of human survival.
17888441 Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study.
12375058 Mitochondrial genotypes and cytochrome b variants associated with longevity or Parkinson's disease.
18316725 Functionally significant insulin-like growth factor I receptor mutations in centenarians.
23460298 Sexual experience restores age-related decline in adult neurogenesis and hippocampal function.
12859354 Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline.
18335035 SirT1 regulates energy metabolism and response to caloric restriction in mice.
22239951 Deciphering the effects of gene deletion on yeast longevity using network and machine learning approaches.
2845344 Extensive defects of mitochondrial electron-transfer chain in muscular cytochrome c oxidase deficiency.
9449878 Mitochondrial genotype associated with longevity.
11792841 Association of human aging with a functional variant of klotho.
7460386 Family analysis of Werner's syndrome: a survey of 42 Japanese families with a review of the literature.
8265666 The gene responsible for Werner syndrome may be a cell division "counting" gene.
11316787 Loss of Werner syndrome protein function promotes aberrant mitotic recombination.
23936746 Aging, neurogenesis, and caloric restriction in different model organisms.
23891729 Autophagy activation and neuroprotection by progesterone in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis.
16356642 Dietary restriction increases hippocampal neurogenesis by molecular mechanisms independent of NMDA receptors.
21471153 The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.
23083790 Genetic inhibition of CETP, ischemic vascular disease and mortality, and possible adverse effects.
1000 The amino acid sequence of Neurospora NADP-specific glutamate dehydrogenase. The tryptic peptides.
42663 [Symposium on major histocompatibility antigens (HLA) and diseases. Supplement: genetic factor in Takayasu disease (author's transl)].
437 Kinetics of cyanate and imidazole binding to hemin in micelles.
56000 [Bacterial flora in patients with prostatic adenoma].
3000 Preparation and storage of platelet concentrates.
20020919 A hierarchical clustering methodology for the estimation of toxicity.
999984 [DNA degradation during standard alkaline of thermal denaturation].
1752787 Fluctuations in tumor blood flow under normotension and the effect of angiotensin II-induced hypertension.
1752803 Effect of supplemental lysocellin and tetronasin on growth, ruminal and blood metabolites, and ruminal proteolytic activity in steers grazing ryegrass.
1752811 Divergent selection for postweaning feed conversion in Angus beef cattle: II. Genetic and phenotypic correlations and realized heritability estimate.
1752808 Simulation of life-cycle efficiency of lamb and wool production for genetic levels of component traits and alternative management options.
1352306 Measurement of amino acid compositions of glycoprotein systems by gas-phase hydrolysis and reversed-phase high-performance liquid chromatography.
1752810 Divergent selection for postweaning feed conversion in Angus beef cattle: I. Mean comparisons.
1352890 Genomes of diploblastic organisms contain homeoboxes: sequence of eveC, an even-skipped homologue from the cnidarian Acropora formosa.
1754223 Nerve-muscle pedicle reinnervation of the paralyzed vocal cord.
1754230 [Non-epithelial malignant neoplasms of the larynx].
1754243 [Use of ultrasonography in the diagnosis of laryngeal cancer].
1754226 The spectrum of vocal dysfunction.
1352315 Quantitative image cytometry of hepatocytes expressing gamma-glutamyl transpeptidase and glutathione S-transferase in diethylnitrosamine-initiated rats treated with phenobarbital and/or phthalate esters.
1752829 Exogenous opioids increase plasma prolactin in Holstein calves primarily via a dopaminergic mechanism.
1754272 Counseling to avoid AIDS.
1754300 Developmental regulation of expression of C-reactive protein and serum amyloid A in Syrian hamsters.
1752838 Reactivity in self-recording: obtrusiveness of recording procedure and peer comments.
1752858 Awakening the sleeping giant: anatomy and plasticity of the brain serotonergic system.
1754299 Prenatal diagnosis and neonatal monitoring of a fetus with glutaric aciduria type II due to electron transfer flavoprotein (beta-subunit) deficiency.
1754289 Adenosine in the pediatric population: nursing implications.
1754297 Oral L-alloisoleucine loading studies in healthy subjects and in patients with maple syrup urine disease.
1754304 Bilirubin-induced changes in brain energy metabolism after osmotic opening of the blood-brain barrier.
1352324 Diabetes incidence in users and non-users of antihypertensive drugs in relation to serum insulin, glucose tolerance and degree of adiposity: a 12-year prospective population study of women in Gothenburg, Sweden.
1754325 [Structure of interstitial nephritis in children].
1752879 Microbial contamination in allografted wound beds in patients with burns.
1352326 Pseudoathetosis as a presenting symptom of spinal multiple sclerosis.
1352327 Brachial plexus neuropathy associated with scrub typhus: report of a case.
23938363 Omics technologies and the study of human ageing.
23746838 The hallmarks of aging.
23594911 Computational solutions for omics data.
23883936 Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease.
1754336 [Results of the treatment of glomerulonephritis in children with hepatitis B].
1752875 Bactericidal and wound-healing properties of sodium hypochlorite solutions: the 1991 Lindberg Award.
1754338 [Crigler-Najjar syndrome in an infant during the 1st year of life].
20404021 Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging.
1752905 Epilepsy and cardiac surgery.
1754356 [Clinical syndromes and treatment tactics in cow's milk intolerance in young children].
1352337 Localization of obscure gastrointestinal bleeding by technetium 99m-labeled red blood cell scintigraphy.
1352336 Detection of mass lesions in the collapsed lung by ultrasonography.
1754384 Molecular cloning of the gene encoding the bovine brain ribonuclease and its expression in different regions of the brain.
1754396 Differential DNA-binding abilities of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cells.
1752961 Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein.
1754417 Dinucleotide repeat polymorphism at D16S287.
1752966 Water deprivation stimulates transforming growth factor-beta 2 accumulation in the juxtaglomerular apparatus of mouse kidney.
1752969 Evaluation of masticatory function following orthognathic surgical correction of mandibular prognathism.
1752968 Restricted opening of the mouth with an extra-articular cause in children.
1352961 Ankylosing spondylitis and HLA-B27: restriction fragment length polymorphism and sequencing of an HLA-B27 allele from a patient with ankylosing spondylitis.
1752922 Clinical use of growth hormone-releasing factor for induction of superovulation.
1752910 Professional oaths--pharmacy can lead the way.
1752914 Comparative pharmacokinetics of temazepam Gelthix and liquid-filled soft gelatin capsules.
1352373 Medicolegal aspects of benzodiazepine dependence. Duties and responsibilities of doctors.
1752976 Guidelines on testing for the lupus anticoagulant. Lupus Anticoagulant Working Party on behalf of the BCSH Haemostasis and Thrombosis Task Force.
1752975 Current concerns in haematology. 3: Blood count calibration.
1752984 Prospective study of quantitative aspects of audit in a large general histopathology laboratory.
1352384 Withdrawal precipitation by benzodiazepine receptor antagonists in dogs chronically treated with diazepam or the novel anxiolytic and anticonvulsant beta-carboline abecarnil.
1352980 B-HT 920 activates dopamine D2 receptors coupled to inhibition of adenylate cyclase activity.
1753022 Meeting the challenge of cancer care and prevention in Europe.
1754503 Association between holoprosencephaly and exposure to topical retinoids: results of the EUROCAT Survey.
23782614 Crowdsourcing for bioinformatics.
23931992 The need for research maps to navigate published work and inform experiment planning.
22162133 Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers.
16904174 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
23972281 EMAP/EMAPA ontology of mouse developmental anatomy: 2013 update.
22973865 A new ontology (structured hierarchy) of human developmental anatomy for the first 7 weeks (Carnegie stages 1-20).
21204651 Bioinformatics in aging research: a workshop report.
23998809 LongevityMap: a database of human genetic variants associated with longevity.
22067257 Epigenetic-aging-signature to determine age in different tissues.
19428454 A case study of "disorganized development" and its possible relevance to genetic determinants of aging.
11283189 Biomarkers of aging: prediction of longevity by using age-sensitive T-cell subset determinations in a middle-aged, genetically heterogeneous mouse population.
23994476 Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression.
24138928 DNA methylation age of human tissues and cell types.
24188080 In-Silico-Approaches and the Role of Ontologies in Aging Research.
23219718 State of the art and open challenges in community-driven knowledge curation.
15355246 Evolutionary and mechanistic theories of aging.
11972154 Mechanisms of ageing: public or private?
17460161 Biological aging is no longer an unsolved problem.
19826117 Qualitative age interactions in breast cancer studies: mind the gap.
18838890 Qualitative age-interactions in breast cancer: a tale of two diseases?
19071000 How age affects the biology of breast cancer.
24293183 Age-related changes in stem cell dynamics, neurogenesis, apoptosis, and gliosis in the adult brain: A novel teleost fish model of negligible senescence.
15542015 Enhancing HMM-based biomedical named entity recognition by studying special phenomena.
23159498 Biomedical text mining and its applications in cancer research.
23948932 Hippocampal neurogenesis in Alzheimer's disease: is there a role for dietary modulation?
25038186 Association between <i>FOXO3A</i> gene polymorphisms and human longevity: a meta-analysis.
24930376 PTK2 rs7460 and rs7843014 polymorphisms and exceptional longevity: a functional replication study.
24924924 Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population.
24792352 Mitochondrial DNA polymorphisms associated with longevity in the Turkish population.
24688116 Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.
24549597 Functional polymorphisms of the leptin and leptin receptor genes are associated with longevity and with the risk of myocardial infarction and of type 2 diabetes mellitus.
24534555 ApoE gene and exceptional longevity: Insights from three independent cohorts.
24468472 Association between the CETP polymorphisms and the risk of Alzheimer's disease, carotid atherosclerosis, longevity, and the efficacy of statin therapy.
24465950 Investigation of complement component C4 copy number variation in human longevity.
24284407 Possible role of -374T/A polymorphism of RAGE gene in longevity.
24244950 Meta‐analysis of genetic variants associated with human exceptional longevity.
24164579 Association of Klotho polymorphisms with healthy aging: a systematic review and meta-analysis.
24163049 The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts.
24126160 Rare and common variants in the Apolipoprotein E gene in healthy oldest old.
23839864 Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)".
23770741 Association analyses of insulin signaling pathway gene polymorphisms with healthy aging and longevity in Americans of Japanese ancestry.
23755540 [Association between 242C > T polymorphism of NADPH oxidase p22phox gene (CYBA) and longevity in Russian population].
23623925 The ACE DD genotype and D-allele are associated with exceptional longevity: a meta-analysis.
23607278 A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family.
23572278 Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans.
23562826 The functional VNTR MNS16A of the TERT gene is associated with human longevity in a population of Central Italy.
23505545 SIRT1 polymorphism, long-term survival and glucose tolerance in the general population.
23450480 [Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi].
23406923 The prion protein M129V polymorphism: longevity and cognitive impairment among Polish centenarians.
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